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Enteric coated pharmaceutical composition and use thereof

A pharmaceutical composition, enteric-coated technology, applied in the field of phosphate binders, can solve unsatisfactory problems

Inactive Publication Date: 2020-09-29
SHIN ERA TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, both aluminum or calcium salts and cross-linked polymers may cause unwanted results and are therefore not ideal

Method used

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  • Enteric coated pharmaceutical composition and use thereof
  • Enteric coated pharmaceutical composition and use thereof
  • Enteric coated pharmaceutical composition and use thereof

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Experimental program
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Embodiment Construction

[0022] The term "chitin citrate" refers to a conjugate comprising a chitin moiety and a citric acid moiety. The chitin moiety and the citric acid moiety are preferably conjugated together through the hydroxyl groups of the chitin moiety. In a more preferred embodiment, the chitin moiety has 50 to 75% deacetylation. In another more preferred embodiment, the chitin moiety has 55 to 70% deacetylation. In yet another more preferred embodiment, the deacetylation of the chitin moiety is 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65% %, 66%, 67%, 68%, 69%, or 70%. In an alternative embodiment, the weight average molecular weight of the chitin fraction is 15,000 to 40,000 Daltons; preferably, the weight average molecular weight is 20,000 to 35,000 Daltons.

[0023] It is generally believed that the higher the degree of deacetylation of the chitin moiety, the more active functional groups available for binding phosphate, thus providing better phosphate binding ability. There...

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Abstract

Provided are an enteric coated pharmaceutical composition and use thereof. The enteric coated pharmaceutical composition comprises chitosan citrate, a pharmaceutically acceptable carrier, and an enteric coating, wherein chitosan citrate is coated by the enteric coating and comprises a chitosan moiety of 50 to 75% deacetylation.

Description

technical field [0001] The present invention relates to a phosphate binder for patients with hyperphosphatemia; in particular, an enteric coated pharmaceutical composition for patients with hyperphosphatemia, which comprises a phosphate binder. Background technique [0002] Hyperphosphatemia is a syndrome in which the serum phosphate level is higher than a certain threshold, resulting in deposition in the body and endangering the circulatory system. There are many diseases that can cause hyperphosphatemia, including kidney disease, kidney failure, hypoparathyroidism, etc. In the advanced stage of the aforementioned disease, the patient's kidney function will be affected by the disease, resulting in a significant increase in the level of phosphate in the blood. [0003] Patients with hyperphosphatemia are advised to follow a low-phosphate diet. However, phosphates are very common in everyday foods. Therefore, it can be very difficult to avoid phosphate-containing foods. B...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/30A61K9/32A61K31/722A61K47/38A61K47/32A61P3/12
CPCA61K31/722A61P3/12A61K9/2846A61K9/2866A61K9/4866A61K9/5026A61K9/5042A61K9/4858A61K9/4875A61K9/2013A61K9/2063A61K9/205A61K9/5015
Inventor 邱启铭洪明舜杨博为杜高闵邱明弘
Owner SHIN ERA TECH