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Eupatorium catarium veldkamp phenylpropanoid compound and application thereof

A technology of phytophenanthine and a compound, applied in the field of medicine, can solve problems such as insufficient research on chemical constituents of Pseudomonas spp., and achieve the effect of good in vitro anti-inflammatory activity

Active Publication Date: 2020-10-16
GUANGDONG PHARMA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As the existing research on the chemical constituents of Pseudomonas is not thorough enough, the specific structure and pharmaceutical functions of its chemical constituents are worthy of further research and development, so as to provide a new way for the resource utilization of this exotic vicious weed

Method used

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  • Eupatorium catarium veldkamp phenylpropanoid compound and application thereof
  • Eupatorium catarium veldkamp phenylpropanoid compound and application thereof
  • Eupatorium catarium veldkamp phenylpropanoid compound and application thereof

Examples

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Effect test

Embodiment 1

[0028] Present embodiment 1 obtains 2 kinds of compounds by extracting and separating from Pseudomonas chinensis, identifies them, and confirms the specific structures of 2 kinds of compounds, wherein the extraction and separation method comprises the following steps:

[0029] (1) Cut 10 kg of the whole plant of Pseudomonas chinensis naturally dried in the shade, and use 75% ethanol to reflux extract at 60° C. for 4 times, each time for 2 hours, to obtain an extraction concentrate (10 L).

[0030] (2) The extract concentrate was extracted three times with equal volumes of cyclohexane, chloroform, ethyl acetate and n-butanol in sequence to obtain a chloroform layer (74.68 g).

[0031] (3) The chloroform portion (74.68g) was subjected to silica gel column chromatography, and gradient elution was performed using dichloromethane-methanol (100:0, 50:1, 20:1, 10:1, 5:1, 3:1 , 0:100; v / v), taking the dichloromethane-methanol eluent with a volume ratio of 50:1 as effective parts X and...

Embodiment 2

[0056] In this example, LPS (lipopolysaccharide) was used to induce BV-2 (mouse microglia) cells to establish an in vitro inflammation model. The cytotoxicity of the samples was tested by MTT, the amount of NO produced by Griess was measured, and the effects of the above compounds 1 and 2 on the release of inflammatory mediator NO by BV-2 cells induced by lipopolysaccharide were investigated, and the anti-inflammatory drug minocycline was used as a positive control.

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Abstract

The invention belongs to the technical field of medicines and discloses a novel eupatorium catarium veldkamp phenylpropanoid compound extracted from eupatorium catarium veldkamp. Animal pharmacodynamic tests show that the novel phenylpropanoid compound has an inhibiting effect on inflammatory mediators NO generated by LPS-induced BV-2 cells, the anti-inflammatory effect is remarkable, and the novel phenylpropanoid compound has no toxicity to the cells, so that the novel phenylpropanoid compound disclosed by the invention can be used for preparing inflammation-related medicines.

Description

[0001] This application is a divisional application of the invention application with the filing date of 2019.10.09, the application number of 201910953807.X, and the invention title of "Pseudoskurenin Compounds and Their Applications". technical field [0002] The invention belongs to the technical field of medicines, and in particular relates to styranidin compounds and applications thereof. Background technique [0003] Inflammation is a defense response of living tissue with vascular system to damaging factors. Most diseases are accompanied by inflammation, which will aggravate the occurrence and development of the disease, and some chronic inflammation may even lead to the occurrence of tumors. Therefore, the control and treatment of inflammation is of great significance. [0004] Natural medicines, especially those derived from plants, have a variety of chemical structures and biological activities, and have always been the main source of human disease prevention and t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D319/20C07C69/736A61P29/00A61P25/00A61P11/00A61P1/16A61P9/00A61P25/28A61K31/216A61K31/357
CPCA61P1/16A61P9/00A61P11/00A61P25/00A61P25/28A61P29/00C07B2200/07C07C69/736C07D319/20C07C2601/14
Inventor 何祥久王宜海肖露徐静雯
Owner GUANGDONG PHARMA UNIV
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