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Reinforcing agent for anti-tumor effect of polymer type anti-cancer drug

A polymer-based, anti-cancer drug technology, applied in anti-tumor drugs, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Insufficient effect, etc.

Inactive Publication Date: 2020-10-20
株式会社纳米超越
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, although conventional anticancer drugs have been confirmed to have a certain therapeutic effect, there are cases where the therapeutic effect is insufficient or varies depending on the case. It is also true that the therapeutic effect achieved by chemotherapy is limited.

Method used

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  • Reinforcing agent for anti-tumor effect of polymer type anti-cancer drug
  • Reinforcing agent for anti-tumor effect of polymer type anti-cancer drug
  • Reinforcing agent for anti-tumor effect of polymer type anti-cancer drug

Examples

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Embodiment

[0082] The following examples illustrate the present invention. However, the present invention is not interpreted as being limited to the following Examples.

[0083] 1. Experimental materials and methods

[0084] 1-1. Cell culture

[0085] In the experiments shown below, two human colorectal cancer cell lines, HCT116 and HT29, were used. HCT116 was cultured using DMEM (Dulbecco's Modified Eagle Medium) (Thermo Fisher Scientific, Waltham, Massachusetts, USA), and HT29 was cultured using RPMI1640 (Loswe Parker). Memorial Institute Medium: Roswell Park Memorial Institute Medium) (Thermo Fisher Scientific). 10% FBS (Fetal Bovine Serum) (BIO-WEST Company, San Marcos, Texas, U.S.) was added to the two culture media, under 5% CO 2 , and cultured in a 37°C incubator.

[0086] 1-2. Preparation of carbonated apatite particles

[0087] 0.37g of NaHCO 3 , 90 μl of NaH 2 PO 4 2H 2 O (1M) and 180 μl of CaCl 2 (1M) was added to 100 ml of distilled water, dissolved completel...

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Abstract

The invention discloses a double-drug preparation type cancer treatment drug, a drug kit thereof and application of anti-tumor effect enhancer related drugs. By administering a reinforcing agent thatcontains apatite carbonate but does not contain a polymer anticancer drug before and after or simultaneously with the administration of the polymer anticancer drug, it is possible to effectively accumulate the polymer anticancer drug in tumor tissue and to sharply enhance the anti-tumor effect of the polymer anticancer drug.

Description

technical field [0001] The present invention relates to an enhancer for enhancing the antitumor effect of polymer anticancer drugs. In addition, the present invention relates to a cancer therapeutic agent using the enhancer. Background technique [0002] In recent years, due to the advancement of cancer treatment drugs and treatment methods, the survival rate of cancer patients has been on the rise. However, cancer is still the number one cause of death in Japan. Even now, more than 300,000 Japanese citizens suffer from cancer every year. And die. [0003] Cancer treatments are broadly classified into surgery, radiation therapy, and chemotherapy. Among them, chemotherapy is a therapy of administering anticancer drugs to cancer patients, and it is applied to preoperative / postoperative adjuvant chemotherapy for eradicating lesions and improving curative power before and after surgical therapy or radiotherapy, or for adjuvant chemotherapy with surgery. In the treatment of ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/42A61K38/38A61K45/06A61K31/7048A61K47/58A61K31/555A61P35/00
CPCA61K33/42A61K38/38A61K45/06A61K31/7048A61K47/58A61K31/555A61P35/00A61K2300/00
Inventor 吴鑫
Owner 株式会社纳米超越