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New application of blood inositol as kidney prognosis diagnostic marker for diabetic nephropathy patient

A technology of diabetic nephropathy and diagnostic markers, applied in disease diagnosis, biomaterial analysis, instruments, etc., can solve the problems of unproven specificity and sensitivity of kidney prognosis

Pending Publication Date: 2020-10-23
蒋松
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, the correlation between blood inositol content and other clinical indicators in patients with type 2 diabetes mellitus complicated with diabetic nephropathy (DN), as well as the correlation between the progress of renal function in patients and renal prognosis, and its use as a non-invasive biomarker Specificity and sensitivity for renal prognosis remain unproven

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  • New application of blood inositol as kidney prognosis diagnostic marker for diabetic nephropathy patient
  • New application of blood inositol as kidney prognosis diagnostic marker for diabetic nephropathy patient
  • New application of blood inositol as kidney prognosis diagnostic marker for diabetic nephropathy patient

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Embodiment 1

[0019] Example 1 Application of Blood Inositol Content as Renal Prognostic Biomarker in Patients with Type 2 Diabetes Mellitus Complicated with Renal Disease

[0020] Blood inositol is derived from the catabolism of sugar in the human body. It is one of the important raw materials for the synthesis of phosphatidylinositol kinase in the body. It is mainly metabolized in the proximal renal tubules of the kidney, and oxygenated by inositol in the renal tubules. Enzyme metabolism into calcium gluconate excreted in urine. In the application of blood inositol as a biomarker for long-term renal prognosis in patients with type 2 diabetes mellitus complicated with diabetic nephropathy (DN), the specific detection methods are:

[0021] (1) Meteorological mass spectrometry detection method

[0022] Dilute the standard substance of inositol to a certain concentration, enter the mass spectrometer for detection, and obtain its peak area and flight time. The peak area has a good linear rel...

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Abstract

The invention provides an application of blood inositol in a kidney prognosis diagnostic marker of a patient suffering from type 2 diabetes mellitus complicated with diabetic nephropathy. The blood inositol content of the patient is used for predicting the kidney function decline degree of the patient and judging the speed of the kidney of the patient for end-to-end renal insufficiency (ESRD); andthe blood inositol comprises all inositol isomers. The invention also provides an application of serum inositol in preparing a kit for diagnosing long-term prognosis of the patient with type 2 diabetes mellitus complicated with diabetic nephropathy (DN). Te kidney long-term prognosis of diabetic nephropathy (DN) can be effectively diagnosed by utilizing the absolute quantification of blood inositol, and the kit has important significance for the diagnosis and treatment of diabetic nephropathy.

Description

technical field [0001] The invention relates to the field of genetic biological preparations, in particular to the new use of blood inositol as a long-term prognosis diagnostic marker for kidneys in patients with type 2 diabetes mellitus complicated with diabetic nephropathy. Background technique [0002] With the increase in the incidence of metabolic diseases such as diabetes and obesity in my country and the aging population, the incidence of diabetic nephropathy (DN) in my country continues to increase. At present, DN has become the most important cause of end-stage renal insufficiency in my country. one. It is of great significance to elucidate the occurrence and development mechanism of chronic kidney disease, and to discover and verify non-invasive biomarkers for early diagnosis and prognosis of DN patients. [0003] Microalbuminuria is currently the most commonly used clinical biomarker for early diagnosis and prognosis in patients with diabetic nephropathy. But in ...

Claims

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Application Information

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IPC IPC(8): G01N33/543
CPCG01N33/543G01N2800/042G01N2800/347G01N2800/52
Inventor 蒋松刘志红
Owner 蒋松
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