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Pharmaceutical preparation, system containing pharmaceutical preparation and preparation method and application of pharmaceutical preparation

A pharmaceutical preparation and preparation technology, applied in the field of pharmaceutical preparations, can solve problems such as the inability to achieve long-term continuous and safe analgesic effects, achieve continuous and safe analgesic effects, avoid serious side effects, and be convenient to use

Inactive Publication Date: 2020-10-27
HUZHOU INNOVATION PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to provide a new type of pharmaceutical preparation, a system containing it and its preparation method, application

Method used

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  • Pharmaceutical preparation, system containing pharmaceutical preparation and preparation method and application of pharmaceutical preparation
  • Pharmaceutical preparation, system containing pharmaceutical preparation and preparation method and application of pharmaceutical preparation
  • Pharmaceutical preparation, system containing pharmaceutical preparation and preparation method and application of pharmaceutical preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] A pharmaceutical preparation, the composition of which is shown in the table below:

[0111] Element mass percent or molar concentration Lidocaine 5％ Disodium phosphate 0.094mol / L Sodium dihydrogen phosphate 0.006mol / L xanthan gum 4％ sodium hydroxide 0.08％ water Top up to 100%

[0112] The preparation method of described pharmaceutical preparation is as follows:

[0113] Add sodium hydroxide, disodium hydrogen phosphate, sodium dihydrogen phosphate and xanthan gum to the water and stir until a homogeneous viscous liquid is obtained. Then, add lidocaine and heat to 80° C., stir rapidly, and cool to room temperature to obtain the product.

[0114] In this pharmaceutical preparation, the pH buffer pair is composed of disodium hydrogen phosphate and sodium dihydrogen phosphate; xanthan gum is a thickener and a suspending agent.

[0115] Effect data: the obtained pharmaceutical preparation is recorded as pharmaceutical...

Embodiment 2

[0117] A pharmaceutical preparation, the composition of which is shown in the table below:

[0118]

[0119]

[0120] The preparation method of described pharmaceutical preparation is as follows:

[0121] Sodium hydroxide, disodium hydrogen phosphate, sodium dihydrogen phosphate, Pemulen TR-2, and hydroxyethylcellulose were added to the water and stirred until a homogeneous viscous liquid was obtained. Then, add lidocaine and glycerin and heat to 80° C., stir rapidly, and cool to room temperature to obtain the obtained product.

[0122] In this pharmaceutical preparation, the pH buffer pair is composed of disodium hydrogen phosphate and sodium dihydrogen phosphate; sodium hydroxide is used to adjust the pH value and participate in the pH buffer pair; Pemulen TR2 is a suspending agent; suspending agent.

[0123] Effect data: The obtained pharmaceutical preparation is recorded as pharmaceutical preparation B, and the obtained pharmaceutical preparation is a viscous solut...

Embodiment 3

[0125] A pharmaceutical preparation, the composition of which is shown in the table below:

[0126]

[0127]

[0128] The preparation method of described pharmaceutical preparation is as follows:

[0129] Sodium hydroxide, disodium hydrogen phosphate, sodium dihydrogen phosphate, Pemulen TR-2, and hydroxyethylcellulose were added to the water and stirred until a homogeneous viscous liquid was obtained. Then, add lidocaine and glycerin and heat to 80° C., stir rapidly, and cool to room temperature to obtain the obtained product.

[0130] In this pharmaceutical preparation, the pH buffer pair is composed of disodium hydrogen phosphate and sodium dihydrogen phosphate; sodium hydroxide is used to adjust the pH value and participate in the pH buffer pair; Pemulen TR2 is a suspending agent; suspending agent.

[0131] Effect data: the obtained pharmaceutical preparation is recorded as pharmaceutical preparation C, and the obtained pharmaceutical preparation is a viscous solut...

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Abstract

The invention discloses a pharmaceutical preparation, a system containing the pharmaceutical preparation and a preparation method and an application of the pharmaceutical preparation. The pharmaceutical preparation comprises water, a pH buffer solution and local anesthetics, wherein the local anesthetics in the pharmaceutical preparation comprise dissolved and undissolved local anesthetics, wherein the mass percentage of the local anesthetic in the pharmaceutical preparation is 2% or above; the pH buffer solution enables the mass percentage of the dissolved local anesthetic in the pharmaceutical preparation to be 1% or below; the local anesthetic is lidocaine, tetracaine, bupivacaine, articaine, cinchocaine, dibucaine, etidocaine, levobupivacaine, mepivacaine, prilocaine, ropivacaine, trimecaine, benzocaine, or procaine; and the sum of the mass percentages of the components in the medicinal preparation is 100%. In many analgesic applications, the pharmaceutical formulation is capable of obtaining a continuous analgesic effect of 6, 12, 18, 24, 36, or even 48 hours or more.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, a system containing it, a preparation method and application thereof. Background technique [0002] Local anesthetic preparations are used to prevent or treat pain on the skin or mucous membranes, for example: 2% lidocaine hydrochloride gel is used to relieve pain associated with sunburn; An emulsion of low-point co-incorporating oil droplets with prilocaine, which is used for anesthesia of intact skin before surgery with pain; Lidoderm, a curing gel patch containing 5% lidocaine, which is used to relieve band Postherpetic neuralgia (the skin itself is intact); Pliaglis is an emulsion containing 7% lidocaine and 7% tetracaine in the form of low-point co-integrating oil drops for painful preoperative intact skin of anesthesia. However, each of the above local anesthetic formulations has serious limitations. For example: lidocaine hydrochloride gel does not anesthetize intact skin; prilocaine in E...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/10A61K9/06A61K9/70A61K31/167A61K31/245A61K31/445A61K47/02A61K47/36A61K47/38A61P23/02A61P25/04
CPCA61K31/167A61K31/245A61K31/445A61K9/08A61K9/10A61K9/06A61K9/0014A61K47/02A61K47/38A61K47/36A61K9/7023A61P23/02A61P25/04A61K9/70
Inventor 张洁唐培克
Owner HUZHOU INNOVATION PHARMACEUTICAL CO LTD
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