A kind of micelle-containing drug-loaded corneal contact lens and preparation method thereof

A technology of corneal contact lens and micelles, which is applied in the field of medicine, can solve the problems of reducing patient compliance, and achieve the effects of increasing bioavailability, delaying drug release, and simple preparation process

Active Publication Date: 2022-06-21
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This significantly reduces patient compliance for chronic diseases such as glaucoma that require long-term treatment

Method used

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  • A kind of micelle-containing drug-loaded corneal contact lens and preparation method thereof
  • A kind of micelle-containing drug-loaded corneal contact lens and preparation method thereof
  • A kind of micelle-containing drug-loaded corneal contact lens and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0050] The invention relates to a preparation method of a micelle-containing drug-loaded corneal contact lens which can be used for glaucoma treatment. Or heat to induce curing, and after demolding, it is immersed in a solvent to remove unreacted monomers to obtain a cross-linked polymer hydrogel contact lens.

[0051] The loaded drugs can be adrenergic agonists, carbonic anhydrase inhibitors, beta blockers, prostanoids and miotics. Such as timolol and latanoprost, but not limited to the drugs for the treatment of glaucoma, characterized by ophthalmic drugs. What is loaded can be that each micelle is loaded with only one drug, and mixed micelles of multiple drugs are obtained after mixing, or one micelle can be loaded with multiple drugs at the same time, preferably, one micelle can be loaded with multiple drugs at the same time. The mentioned loaded polymer materials can be PEG-PLA, PEG-PLGA, PEG-PCL, etc., which can form micelles, but are not limited to PEGs, which are char...

Embodiment example 1

[0058] Example 1 Preparation of drug-loaded contact lenses in micelles

[0059] (1) Preparation of polymer micelles

[0060] Combine timolol, and latanoprost total drug 10mg (1:10) with 30mg PEG 2000 -PLA 2400 The polymeric micelle material was dissolved in acetonitrile. A thin uniform film on the flask wall was formed under vacuum rotary evaporation. Homogeneous films were hydrated in deionized water, spun moderately at 20-60°C, and then filtered through a 0.22 μm. filter to remove large particles.

[0061] (2) Preparation of drug-containing micellar contact lenses

[0062] Weigh 0.9g monomer 2-hydroxyethyl methacrylate, add 0.5g micelles loaded with timolol and latanoprost, add 0.025g ethylene dimethacrylate as a crosslinking agent, 0.025 g g of Darocur 1173 was used as an initiator, stirred evenly, degassed, added to a polypropylene contact lens mold, and cured for 30 min under an ultraviolet lamp with a wavelength of 365 nm to obtain a hydrogel contact lens. The ligh...

Embodiment example 2

[0067] Example 2 Preparation of micellar drug-loaded contact lenses

[0068] (1) Preparation of polymer micelles

[0069] Timolol, and latanoprost total drug 10 mg (1:10) and 50 mg PEG2000-PLA2400 polymeric micelle material were dissolved in acetonitrile. A thin uniform film on the flask wall was formed under vacuum rotary evaporation. The homogeneous film was hydrated in deionized water, spun moderately at 20-60°C, and then filtered through a 0.22 μm. filter to remove large particles.

[0070] (2) Preparation of drug-containing micellar contact lenses

[0071] Weigh 0.9g monomer 2-hydroxyethyl methacrylate, add 0.5g micelles loaded with timolol and latanoprost, add 0.025g ethylene dimethacrylate as a crosslinking agent, 0.025 g g of Darocur 1173 was used as an initiator, stirred evenly, degassed, added to a polypropylene contact lens mold, and cured for 30 min under an ultraviolet lamp with a wavelength of 365 nm to obtain a hydrogel contact lens. The light transmittance ...

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Abstract

The invention belongs to the technical field of medicine, and relates to a micelle-containing drug-loaded corneal contact lens and a preparation method thereof, in particular to one or more polymer micelles, polymerized monomers, and cross-linked copolymers for treating glaucoma. Contact lenses made of cross-linked polymer hydrogels. In the invention, the medicine is first encapsulated in the polymer micelles through the film hydration method, and then the drug-loaded micelles are loaded into the corneal contact lens by photopolymerization or thermal curing. The drug-loaded corneal contact lens prepared by the invention utilizes the property of prolonging the release of the drug encapsulated in micelles, prolongs the release time of the drug in the drug-loaded contact lens, improves the ocular bioavailability of the drug, and is used for treating glaucoma.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a micellar-containing drug-loaded corneal contact lens and a preparation method thereof, in particular to a micellar-containing drug-loaded corneal contact lens obtained by ultraviolet light or heat-induced curing that can be used for glaucoma treatment The drug-loaded corneal contact lens can significantly improve the bioavailability and is used for treating glaucoma. Background technique [0002] Glaucoma is a chronic optic neuropathy that affects approximately 60.5 million people worldwide and causes 8.5 million blindness due to the disease. Glaucoma has become the second leading cause of blindness after cataracts. The World Health Organization estimates that by 2020, the number of cases of blindness due to glaucoma will increase to 12 million. At present, intraocular pressure (IOP) is still recognized as a major risk factor for the development of glaucoma, and lowering IOP c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K47/34A61K45/00A61K31/5575A61K31/5377A61P27/06G02C7/04
CPCA61K9/1075A61K47/34A61K45/00A61P27/06G02C7/04
Inventor 张宇唐星尹湉何海冰苟靖欣许佳文
Owner SHENYANG PHARMA UNIVERSITY
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