Application of idelalisib in preparation of medicine for treating hepatic fibrosis diseases
A liver fibrosis and drug technology, which is applied in the application field of Adeleris in the preparation of drugs for the treatment of liver fibrosis, can solve the problems of inhibiting tumor cell chemotaxis and adhesion, reducing cancer cell viability, etc.
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[0021] Effects of Aldelaris on Carbon Tetrachloride-Induced Liver Fibrosis in Mice
[0022] Preparation of liver fibrosis animal model: take C57BL / 6J, (age 8-10 weeks) wild-type mice, give the mice intraperitoneal injection anesthesia with a mass fraction of 10% chloral hydrate at 0.5mL / 100g (body weight), and anesthetize The mice were weighed and recorded and injected intraperitoneally with 20% 1ml / kg carbon tetrachloride (olive oil as solvent), 3 times / week for 8 weeks.
[0023] Grouping situation: the control group was intraperitoneally injected with the same volume of olive oil; the model group was modeled according to the above method, and the corresponding solvent olive oil was injected intraperitoneally from the first day after carbon tetrachloride treatment until the end of the experiment; From the 29th day to the 56th day of carbon tetrachloride treatment, the test ended. The low-dose group was given 30 mg / kg Idelaris to the mice by intragastric administration every d...
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