Compositions and methods for neuroprotection utilizing nanoparticulate silver

A technology of neuroprotection and silver nanoparticles, applied in the field of nanoparticle metals, can solve problems such as unclear mechanisms

Inactive Publication Date: 2020-11-13
AVALON NANOSILVER RXHK LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanisms behind these effects are unclear

Method used

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  • Compositions and methods for neuroprotection utilizing nanoparticulate silver
  • Compositions and methods for neuroprotection utilizing nanoparticulate silver
  • Compositions and methods for neuroprotection utilizing nanoparticulate silver

Examples

Experimental program
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Embodiment

[0056] Preparation of silver nanoparticles (AgNPs)-loaded hyaluronic acid / methylcellulose (HAMC) hydrogel: Silver nanoparticles (AgNPs) in suspension were synthesized using a chemical reduction method. 0.7 mM sodium citrate dihydrate (Sigma-Aldrich) and 0.1 mM silver nitrate (AgNO 3 ; Sigma-Aldrich) was bubbled and vigorously stirred at room temperature for 30 minutes under nitrogen. Add 0.5ml of 10mg / ml sodium borohydride (NaBH 4 ; Sigma-Aldrich) solution and then stirred for 4 hours (to completion) in the dark. After overnight aging, the solution was concentrated from 500 ml to 50 ml by rotary evaporation, and 50 μl of 100 mg / ml polyvinylpyrrolidone (PVP; Mr = 10,000 Da; Sigma-Aldrich) was added as a stabilizer to prevent aggregation of AgNPs during storage. The obtained AgNPs suspension had a final concentration of approximately 1 mM (in mass of Ag per volume).

[0057] Using 2wt% sodium hyaluronate (HA; MW=2,600Da; Ryon) and 5wt% methylcellulose (MC; MW=300Da; Sigma-Ald...

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Abstract

A preparation of silver nanoparticles has been found to be effective in improving functional and behavioral recovery from traumatic spinal cord injury. The silver nanoparticles are provided in a non-flowable gel vehicle, from which they are release at high efficiency, that is applied locally at the site of the spinal cord injury. Silver nanoparticle formulations described herein were found to modify the M1 / M2 macrophage phenotype ratio and provides a synergistic effect in the combination with arginase to promote healing processes at the treated injury site, reducing postinjury inflammation.

Description

[0001] This application claims the benefit of U.S. Provisional Application No. 62 / 462,145, filed February 22, 2017. These and all other referenced external materials are hereby incorporated by reference in their entirety. If the definition or use of a term in a reference incorporated by reference is inconsistent or contrary to the definition of that term provided herein, the definition of that term provided herein is deemed to be controlling. technical field [0002] The field of the invention is the prevention and / or treatment of neurological damage, in particular using nanoparticulate metals. Background technique [0003] The Background Description includes information useful in understanding the present invention. It is not an admission that any information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art. [0004] Traumatic Spinal Cord Injury (TSCI) is a serious condi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61K39/395A61K9/08A61K9/06A61K47/30A61P25/00
CPCA61K33/38A61P25/00A61K47/36A61K9/14A61K45/06A61K9/06A61P29/00A61K47/38A61K9/5138A61K2300/00A61P25/28A61K38/50
Inventor 刘耀南杜启峻张文智
Owner AVALON NANOSILVER RXHK LTD
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