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A kind of test method of the gelation temperature of thermosensitive hydrogel

A temperature-sensitive hydrogel and testing method technology, applied in the field of gelation temperature testing, can solve the problems of large influence of subjective factors, hydrogel structure damage, dependence on thermal effect or frequency, etc., to achieve repeatability and stability Good, high data reliability, simple and quick judgment

Active Publication Date: 2022-04-01
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the rheological method, the gel point obtained by equal viscous modulus and elastic modulus may be frequency-dependent, which will bring some errors; and the test process needs to apply rotational shear to the hydrogel, resulting in hydraulic Destruction of the glue structure
[0006] Combining the above existing technologies, it can be known that the existing test methods for the gelation process of thermosensitive hydrogels have many problems such as subjective factors, dependence on thermal effects or frequency, long test time, etc., and the detection process may also be accompanied by water. Destruction of gel structure and properties, which is not conducive to specific detection requirements

Method used

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  • A kind of test method of the gelation temperature of thermosensitive hydrogel
  • A kind of test method of the gelation temperature of thermosensitive hydrogel
  • A kind of test method of the gelation temperature of thermosensitive hydrogel

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Embodiment 1

[0051] A test method for the gelation temperature of thermosensitive hydrogel is carried out by low-field nuclear magnetic resonance relaxation technology (LF-NMR), specifically comprising the steps of:

[0052] (1) Sample preparation: under the conditions of ice bath and stirring, slowly add 50% disodium glycerophosphate (GP) dropwise to 2% chitosan (CS) solution dissolved in 0.1M hydrochloric acid to obtain CS quality 100% A CS-GP temperature-sensitive hydrogel precursor with a content of 1.6% and a mass percentage of GP of 10% was stored at 4°C for subsequent use after measuring the pH value;

[0053] (2) Take 1mL of the CS-GP temperature-sensitive hydrogel precursor obtained in step (1) and place it in a 12mm×36mm borosilicate glass tube. After setting the instrument parameters, perform online temperature control on the sample. The NMR signal decay curve of the sample at 5-40°C is inverted to obtain the transverse relaxation time T 2 Distribution curve, test temperature p...

Embodiment 2

[0058] A test method for the gelation temperature of a thermosensitive hydrogel, the only difference between it and Example 1 is that the sample prepared in step (1) is 1.6% by mass of CS and 1.6% by mass of GP. 7% CS-GP temperature-sensitive hydrogel precursor; other test steps are the same as in Example 1.

Embodiment 3

[0060] A test method for the gelation temperature of a thermosensitive hydrogel, the only difference between it and Example 1 is that the sample prepared in step (1) is 1.6% by mass of CS and 1.6% by mass of GP. 8% CS-GP temperature-sensitive hydrogel precursor; other test steps are the same as in Example 1.

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Abstract

The invention provides a test method for the gelation temperature of thermosensitive hydrogel, said test method is carried out by low-field nuclear magnetic resonance relaxation technique, comprising the following steps: (1) testing thermosensitive hydrogel at different temperatures The gel precursor was measured by low-field NMR to obtain the transverse relaxation time T at different temperatures 2 Distribution curve; (2) Transverse relaxation time T obtained according to step (1) 2 The distribution curve determines the T corresponding to the water in the polymer network 21 peak, and obtain the T 21 The intensity value of the peak; (3) establishing a curve between the intensity value obtained in step (2) and the corresponding temperature, and obtaining the gelation temperature according to the inflection point of the curve. The test method accurately captures the changes in the mobility of water molecules in the hydrogel system through low-field nuclear magnetic resonance relaxation technology, thereby obtaining a complete curve of the gelation process and the gelation temperature, which is fast, accurate, and highly sensitive. , Non-invasive and non-destructive characteristics.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a method for testing the gelation temperature of thermosensitive hydrogels. Background technique [0002] Temperature-sensitive hydrogels (thermo-sensitive hydrogels) have the characteristics of being able to undergo solution-gel transitions under the stimulation of ambient temperature. This environmental responsiveness makes them have good applications in biomedicine, biotechnology and other fields. promising, especially suitable as an injectable in situ hydrogel drug release carrier. The gelation temperature and gelation temperature of thermosensitive hydrogels are the key factors to determine whether they can become suitable body temperature sensitive hydrogels, so the characterization of the gelation characteristics of thermosensitive hydrogels is very important for its application. very important. [0003] The temperature-sensitive hydrogel system has...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N24/08G01N25/20
CPCG01N24/08G01N25/20
Inventor 李秀男陈芳宇陈超赵大伟张松平苏志国
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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