Adhesive self-repairing hemostatic membrane and preparation method thereof

A self-healing, hemostatic film technology, used in pharmaceutical formulations, bandages, drug delivery, etc., can solve the problems of high swelling rate, poor wound adhesion performance, poor adhesion performance, etc., achieve high mechanical strength, and accelerate hemostasis efficiency. Effect

Active Publication Date: 2021-09-28
SHANDONG BRANDEN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the electrospun fiber membrane still has the disadvantages of not being easy to degrade and having poor adhesion to wounds.
[0006] The common Daqing absorbable hemostatic film on the market has the disadvantages of high swelling rate after absorbing blood, low mechanical properties, and poor adhesion

Method used

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  • Adhesive self-repairing hemostatic membrane and preparation method thereof
  • Adhesive self-repairing hemostatic membrane and preparation method thereof
  • Adhesive self-repairing hemostatic membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1: Graft oxidized alginic acid with a mass fraction of 2.5% of dopamine (the degree of oxidation is 85%, the grafting rate of dopamine is 15%, and the viscosity is 300 mPa·s), 30% acrylamide, and 5% acrylic acid N-hydroxyl Add succinimide ester and 0.015% N,N'-methylenebisacrylamide into purified water, stir at 100-200rpm until completely dissolved, continue stirring for 20min, add 1.6% 2-hydroxy-2-methyl -1-[4-(2-Hydroxyethoxy)phenyl]-1-propanone, 20% acrylic acid and 0.6% calcium chloride, stir at 100-200rpm until the solution is uniform, at a power of 150W, a wavelength of 365nm , pre-polymerized under ultraviolet light for 30 minutes, took out the prepolymer, sprayed 1.0% acrylate PEG-N hydroxysuccinimide ester, 0.6% dopamine, 0.4% acrylamide, 3% acrylic acid N-hydroxysuccinimide on the surface A mixture of urethane and 0.018% 2-hydroxy-2-methyl-1-[4-(2-hydroxyethoxy)phenyl]-1-propanone, under a UV lamp with a power of 150W and a wavelength of 365nm Polymer...

Embodiment 2

[0052] Example 2 Graft oxidized alginic acid with a mass fraction of 3.5% dopamine (oxidation degree is 80%, dopamine grafting rate is 10%, viscosity is 200mPa·s), 25% acrylamide, 3% acrylic acid N-hydroxyl Add succinimide ester and 0.020% N,N'-methylenebisacrylamide into purified water, stir at 100-200rpm until completely dissolved, continue stirring for 20min, add 1.6% 2-hydroxy-2-methyl -1-[4-(2-hydroxyethoxy)phenyl]-1-propanone, 25% acrylic acid and 0.4% calcium chloride, stir at 100-200rpm until the solution is uniform, at a power of 150W, a wavelength of 365nm , pre-polymerized under ultraviolet light for 20 minutes, took out the prepolymer, sprayed 1.5% acrylate PEG-N hydroxysuccinimide ester, 1.25% dopamine, 0.6% acrylamide, 4% acrylate N-hydroxysuccinimide on the surface A mixture of urethane and 0.028% 2-hydroxy-2-methyl-1-[4-(2-hydroxyethoxy)phenyl]-1-propanone, under a UV lamp with a power of 150W and a wavelength of 365nm Polymerize for 15min. The polymerized ge...

Embodiment 3

[0053] Example 3 Graft oxidized alginic acid with a mass fraction of 1.5% of dopamine (the degree of oxidation is 90%, the grafting rate of dopamine is 20%, and the viscosity is 500 mPa·s), 35% acrylamide, and 7% acrylic acid N-hydroxyl Add succinimide ester and 0.010% N,N'-methylenebisacrylamide into purified water, stir at 100-200rpm until completely dissolved, continue stirring for 20min, add 1.6% 2-hydroxy-2-methyl -1-[4-(2-Hydroxyethoxy)phenyl]-1-propanone, 15% acrylic acid and 0.5% calcium chloride, stir at 100-200rpm until the solution is uniform, at a power of 150W, a wavelength of 365nm , pre-polymerized under ultraviolet light for 40 minutes, took out the prepolymer, sprayed 0.5% acrylate PEG-N hydroxysuccinimide ester, 0.25% dopamine, 0.2% acrylamide, 2% acrylate N-hydroxysuccinimide on the surface A mixture of urethane and 0.009% 2-hydroxy-2-methyl-1-[4-(2-hydroxyethoxy)phenyl]-1-propanone, under a UV lamp with a power of 150W and a wavelength of 365nm Polymerize ...

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Abstract

The invention discloses an adhesive self-repairing hemostatic membrane and a preparation method thereof. The hemostatic film is fully reacted by dopamine-grafted oxidized alginic acid, acrylic acid N-hydroxysuccinimide ester, N,N'-methylenebisacrylamide, adding coagulation cross-linking agent, acrylic acid and the first part of photoinitiated agent, after pre-polymerization, add the mixture of acrylate PEG‑N hydroxysuccinimide ester, dopamine, acrylamide, acrylate N‑hydroxysuccinimide ester and the second part of photoinitiator, after sufficient polymerization, the program Prepared by vacuum drying. The hemostatic film prepared by the invention can quickly absorb interface moisture, make the interface of the hemostatic film fully contact with the tissue interface, form strong adhesion to the tissue through covalent bonds and intermolecular forces, cause mechanical compression to damaged blood vessels, and promote hemostasis. After the hemostatic membrane absorbs blood or tissue fluid, it can form a dynamic bond and has a certain self-repair function. Therefore, the hemostatic film has the effects of fast and efficient hemostasis, adhesion and self-repair.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to an adhesive self-repairing hemostatic membrane and a preparation method thereof. The medical hemostatic film of the present application has the functions of fast hemostasis, adhesion, displacement prevention and self-repair. Background technique [0002] In the first aid of sudden accidents, surgery and in war, 50% of the deaths are caused by massive bleeding. Some traditional hemostatic materials, such as hemostatic gauze, hemostatic bandage, hemostatic cotton yarn, etc., have limited hemostatic ability, and the hemostatic effect is not very satisfactory. Therefore, the development of highly efficient and quickly absorbable hemostatic materials and products, which can effectively stop bleeding within 1-2 minutes or even shorter after the bleeding occurs, has become one of the main goals of the research and development of hemostatic materials. Hemostatic film is a ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/24A61L15/28A61L15/42C08F285/00C08F220/36C08F220/56C08L51/00C08J5/18
CPCA61L15/24A61L15/28A61L15/42A61L2400/04C08F285/00C08J5/18C08J2351/00C08F220/36C08F220/56C08L51/00C08L5/04
Inventor 张海军袁坤山张淑欣车超越侯文博尹玉霞鲁守涛段翠海
Owner SHANDONG BRANDEN MEDICAL DEVICE
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