Transdermal drug delivery device and control method of ultrasonic cyclic focused emission
A technology of transdermal drug delivery and ultrasonic circulation, which is applied in the field of medical devices and can solve problems such as inability to effectively push drug particles and strong penetration
Active Publication Date: 2022-03-25
NANJING UNIV
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Problems solved by technology
[0005] These devices can carry out targeted drug delivery and improve the efficiency of ultrasonic transdermal drug delivery to a certain extent, but there are still some shortcomings: the focus area in the ultrasonic field is where the intensity of the sound wave is the highest and the vibration direction of the particle is vertical to the depth direction. The drug particles have the strongest penetration effect deep into the human body, and these devices only have one focus position, which cannot effectively push the drug particles for a long distance in the depth direction
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[0032] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.
[0033] Such as figure 1 As shown, the ultrasound transducer array is in close contact with the drug pool on the skin surface. The transducer array is in a linear form, with a total of N array elements. The width of each array element is L, and the interval between adjacent array elements is dL. The ultrasonic emission is controlled by the ultrasonic host, and the focus is achieved by driving the signal phase differently during emission. Move, move the emission focus from shallow to deep, form a continuous downward driving force, and push the drug particles to reach the target area.
[0034] Such as figure 2 As shown, firstly, the operator sets the drug emission parameters according to the medical image observation of the lesion, and then the ultrasound host automatically calculates the number and position of the focal points, the number an...
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The invention discloses a transdermal drug delivery device and a control method for ultrasonic cyclic emission. The device includes an ultrasonic host and a transducer array. The ultrasonic host controls the transducer array to emit ultrasonic waves. The focusing mode of the transducer array is through Realized by phase modulation; the control method includes automatically performing cyclic focused emission and automatically moving the sound beam for drug delivery one by one, and adopting cyclic focused emission can form a continuous vertically stronger sound field in the direction of depth on the transdermal drug delivery path, In this way, continuous driving force is given to the drug particles, which is beneficial for them to reach the deeper subcutaneous lesions and better penetrate the drugs.
Description
technical field [0001] The invention relates to a transdermal drug delivery device and a control method for ultrasonic circular focused emission, belonging to the technical field of medical devices. Background technique [0002] Ultrasound is a mechanical vibration with a vibration frequency exceeding 20,000 Hz, which is generally generated by an ultrasonic transducer and can propagate in solids, liquids, and gases. Ultrasound with a certain power can be used in medical treatment, transdermal drug delivery, physical therapy and beauty treatment, etc. In order to achieve more convenient control and more powerful functions, several ultrasonic transducers are generally combined into an array, and different ultrasonic waves are emitted under the control of the control circuit to meet different business needs. [0003] Transdermal drug delivery refers to a treatment method that uses physical or chemical methods to make the drug penetrate the skin and enter the circulatory system...
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IPC IPC(8): A61M37/00A61N7/02
CPCA61M37/0092A61N7/02A61M2037/0007A61N2007/0004A61N2007/0078
Inventor 章东薛洪惠屠娟宋人杰郭霞生
Owner NANJING UNIV