Application of mesenchymal stem cells in regulation and control of monocytes of viral infection patients

A viral infection and mesenchymal stem cell technology, applied in the field of biomedical engineering, can solve the problems of delayed virus clearance, secondary infection, excessive immune activation and rapid transformation of immune suppression, etc., to achieve suppression of excessive immune response, effective treatment, and alveolar function The effect of protection

Inactive Publication Date: 2020-12-11
HUNAN YUANPIN CELL TECH CO LTD
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  • Abstract
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Problems solved by technology

The main solution in the existing technology is the use of glucocorticoids, but due to the rapid transformation of immune overactivation and immunosuppression in patients with viral infections, the use of glucocorticoids has the risk of delaying virus clearance and secondary infection

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  • Application of mesenchymal stem cells in regulation and control of monocytes of viral infection patients
  • Application of mesenchymal stem cells in regulation and control of monocytes of viral infection patients

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Embodiment Construction

[0022] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0023] It should be noted that the conventional treatment plan mentioned in the present invention refers to the treatment plan adopted in the new coronavirus pneumonia diagnosis and treatment plan issued by the General Office of the National Health Commission and the Office of the State Administration of Traditional Chinese Medicine. MSC+ means the MSC treatment group, MSC- indicates the conventional treatment group.

[0024] Such as figure 1 As shown, a kind of mesenchymal stem cells (mesenchymal stem cells, MSC) is used to regulate the application of monocytes in patients with viral infection, by applying mesenchymal stem cells to regulate monocyte gene expression and regulate monocyte toxicity genes Expression to achieve effective treatment o...

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Abstract

The invention particularly discloses application of mesenchymal stem cells in regulation and control of monocytes of viral infection patients, relates to the technical field of biological medicines, and particularly relates to application in regulation and control of monocyte gene expression and monocyte toxic gene expression of the viral infection patients. According to the application, a mesenchymal stem cell preparation is brought into a conventional treatment scheme to perform combined treatment on the viral infection patients in an MSC treatment group, so that effective regulation and control of the monocyte gene expression and the monocyte toxic gene expression of the viral infection patients are realized, and as a result, the in-vivo excessive immune response of the patients can beeffectively inhibited in time, the in-vivo alveolar function of the patients is protected, and the damage to the lungs and the organs of the whole body of the viral infection patients is reduced. Therefore, the mesenchymal stem cells can effectively treat complications of the viral infection patients by virtue of an immune regulation mechanism, an anti-inflammatory effect and the characteristic ofrepairing damaged tissues.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering, in particular to an application of mesenchymal stem cells for regulating monocytes of patients with viral infection. Background technique [0002] Viral infection refers to an infectious disease caused by a virus that can parasitize and reproduce in the human body. The main manifestations are systemic poisoning symptoms such as fever, headache, and general malaise, and local symptoms caused by inflammation and damage caused by the virus host and invading tissues and organs. Patients with viral infection are prone to induce cytokine storm, inflammatory response, and various complications. And viral infections (such as influenza, SARS, MERS and Ebola) spread rapidly among humans, posing a huge threat to human health. Especially the novel coronavirus (COVID-19 virus) that broke out in the world in 2020 has caused serious losses to human health and economy. The causative agent of CO...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/51A61P31/12A61P11/00C12N5/0775
CPCA61K35/51A61P31/12A61P11/00C12N5/0668C12N2509/00
Inventor 华江舟李伟林吕波周敏蒋雨薇周小明
Owner HUNAN YUANPIN CELL TECH CO LTD
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