Synthesis and application of heteroatom polycyclic aromatic hydrocarbon-containing multi-type organelle fluorescent probe

A technology of polycyclic aromatic hydrocarbons and fluorescent probes, which is applied in the direction of fluorescence/phosphorescence, instruments, and luminescent materials, etc. It can solve the problems of cumbersome synthesis routes, low yields, low atom/step economy, etc., and achieve good photostability , The synthesis route is simple, and the effect of biocompatibility is good
CN112062771AActive Publication Date: 2020-12-11SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SICHUAN UNIV
Publication Date
2020-12-11

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Abstract

The invention relates to synthesis and application of a heteroatom polycyclic aromatic hydrocarbon-containing multi-type organelle fluorescent probe. The fluorescent probe disclosed by the invention can be used for specifically targeting lysosome, endoplasmic reticulum, mitochondria and mitochondrial cell nucleus, and is applied to fluorescence imaging, labeling, tracing and biological treatment.According to the synthesis method, rhodium catalytically activated C=X (X is N, O, S, NR) and alkyne are subjected to [4+2] oxidative cyclization reaction, and the heteroatom-doped polycyclic aromatichydrocarbon (PAHs) derivative with various structures is efficiently and rapidly synthesized by utilizing acridone and analogues thereof which are cheap and easy to obtain. Compared with a traditional reaction system, the method not only realizes high-throughput rapid synthesis of various heteroatom doped polycyclic aromatic hydrocarbon (PAHs) derivatives, but also has the advantages of simple and convenient operation, mild conditions, low cost and the like, can rapidly establish a fluorescent functional molecular library with powerful functions, and has huge potential commercial value.
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Description

technical field

[0001] The present invention relates to the synthesis and application of four types of heteroatom-doped polycyclic aromatic hydrocarbon fluorescent probes with specific targeting multi-type organelles. Background technique

[0002] With the vigorous development of life science disciplines, people's research on subcellular organelles continues to deepen. As the main organelles of eukaryotic cells, lysosome, endoplasmic reticulum, mitochondria and nucleus undertake necessary and important life activities. Lysosome is the "digestive organ" of the cell organelle, and the various acid hydrolytic enzymes contained in the lysosome keep the pH value of the internal environment in the range of 4.5-5.0. As an important acidic organelle in eukaryotic cells, lysosomes have important functions of intracellular digestion and regulation of secretion. At the same time, its quantity and distribution are abnormal, which may cause various diseases such as lung diseases, lysos...

Claims

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