Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of arsenic trioxide to treatment of gastrointestinal stromal tumor

A technology for gastrointestinal stromal tumors and arsenic trioxide, which is applied in the field of medicine to achieve the effects of improving curative effect, good health and economic effects, and reducing economic burden

Inactive Publication Date: 2020-12-15
HANGZHOU FIRST PEOPLES HOSPITAL
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there are no studies on the use of arsenic trioxide in the treatment of gastrointestinal stromal tumors secondary to imatinib resistance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of arsenic trioxide to treatment of gastrointestinal stromal tumor
  • Application of arsenic trioxide to treatment of gastrointestinal stromal tumor
  • Application of arsenic trioxide to treatment of gastrointestinal stromal tumor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0016] To detect the effect of arsenic trioxide on the proliferation, cycle and apoptosis of gastrointestinal stromal tumor cells. Divided into: arsenic trioxide group, negative control group. CCK-8 method was used to detect the effect of medication on cell proliferation in each group, arsenic trioxide group (μg / mL): 0, 0.1, 1, 2, 4, 8, and it was found that the inhibition rate of arsenic trioxide was close to 50% at a concentration of 2ug / mL. The effect of drugs on cell cycle and apoptosis was detected by flow cytometry AnnexinV-FITC / PI double staining technique, arsenic trioxide group: 2ug / mL. The protein extracted from the two groups of cells after drug treatment was detected by Western blot method to detect the expression changes of cell proliferation transcription-related proteins in Imatinib-resistant GIST cells before and after drug treatment. Nude mice of BALB / C / nu / nu strain, aged 3 to 4 weeks, with a body weight of 19.0 ± 2.0 g. Gastrointestinal stromal tumor dru...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of arsenic trioxide to treatment of gastrointestinal stromal tumor. The arsenic trioxide is used for preparing an arsenic trioxide-containing drug for treating imatinib-resistant gastrointestinal stromal tumor, and can improve the sensitivity of gastrointestinal stromal tumor to imatinib and promote cancer cell apoptosis by inhibiting cell proliferation related PI3K / AKT / mTOR pathways. The arsenic trioxide can overcome the drug resistance of the gastrointestinal stromal tumor to the imatinib, and has good hygienic and economic effects.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a new application of a classic drug, arsenic trioxide, which is an application to the unsolved problem of drug resistance of gastrointestinal stromal tumors, and greatly relieves the economic burden of patients. Background technique [0002] Gastrointestinal stromal tumors are the most common mesenchymal tumors of the gastrointestinal tract. The initial curative effect of imatinib targeted therapy is remarkable. However, after an average of 24 months of treatment, drug resistance will develop, which will greatly affect the prognosis of patients. Therefore, Secondary resistance to imatinib is a major clinical difficulty. Arsenic trioxide, or arsenic, is a classic of using poison as medicine. It has achieved outstanding curative effect in the treatment of acute promyelocytic leukemia, and can induce cell apoptosis. At present, there is no relevant research on the use of arsenic trioxide in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K33/36A61P35/00
CPCA61K33/36A61P35/00
Inventor 郑松陆一丹舒叶菲房昕孙杨承柏玉蓉
Owner HANGZHOU FIRST PEOPLES HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com