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Preparation method and product of a platinum nanocrystal composite nanomaterial

A composite nanomaterial, platinum nanotechnology, applied in non-active ingredient medical preparations, drug combinations, pharmaceutical formulations, etc., can solve problems such as blood toxicity and ototoxicity, achieve controllable conditions, good biological safety, good The effect of the possibility of clinical translation

Active Publication Date: 2020-01-17
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, cisplatin can cause severe nephrotoxicity, gastrointestinal toxicity, hematological toxicity, and ototoxicity, including renal tubular damage.
Moreover, the accumulation of cisplatin in the patient's body is also a potential risk factor
[0005] In recent years, second-generation and third-generation platinum drugs have emerged in an endless stream, such as carboplatin, oxaliplatin, sabac, and picoplatin. Although there have been some improvements, so far no platinum drug can replace cisplatin. platinum

Method used

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  • Preparation method and product of a platinum nanocrystal composite nanomaterial
  • Preparation method and product of a platinum nanocrystal composite nanomaterial
  • Preparation method and product of a platinum nanocrystal composite nanomaterial

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Synthesis of small-sized platinum nanocrystals: mix 80mg platinum acetylacetonate with 7ml oleylamine, 0.09ml oleic acid, stir at 70°C for 1 hour under vacuum condition, raise to 170°C at a speed of 5°C / min; Inject lithium-based lithium borohydride into the reaction system, age for 5 minutes, precipitate with acetone, and centrifuge to obtain small-sized platinum nanocrystals.

[0047] Carry out X-ray diffraction analysis to the small-sized platinum nanocrystal that obtains, the result is as attached figure 1 shown; the morphology of small-sized platinum nanocrystals was characterized by transmission electron microscopy, and the results are shown in the attached figure 2 As shown, the particle size is between 2 and 4 nm.

Embodiment 2

[0049] Synthesis of small-sized platinum nanocrystals: 80mg platinum acetylacetonate, 5ml oleylamine, 0.05ml oleic acid, stirred at 70°C for 2 hours under vacuum condition, raised to 170°C at a speed of 5°C / min; Inject lithium-based lithium borohydride into the reaction system, age for 30 minutes, precipitate with acetone, and centrifuge to obtain platinum nanocrystals. The obtained platinum nanoparticles have a size of 4-6 nm.

Embodiment 3

[0051] Preparation of platinum nanocrystal composite nanomaterials: 1.2 mg of small-sized platinum nanocrystals (prepared according to the method in Example 2) and 20 mg of poloxamer P188 were dispersed in chloroform, stirred at room temperature for 1 hour, and evaporated under reduced pressure to remove the organic solvent. Add 3ml of PBS (pH 7.4) for hydration to obtain a platinum nanocrystal composite nanomaterial.

[0052] The particle size distribution of platinum nanocrystalline composite nanomaterials obtained by dynamic light scattering analysis, the results are shown in the attached image 3 shown.

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Abstract

The invention relates to a preparation method of a platinum nanocrystal composite nanomaterial. The method comprises the following steps: (1) dissolving platinum acetylacetonate into oleylamine and oleic acid, and stirring at the temperature of 50-100 DEG C under the vacuum condition; heating up to 150-250 DEG C, continuously adding lithium triethylborohydride, carrying out reaction for 1-60min, and precipitating a poor solvent to obtain small-sized platinum nanocrystals; (2) carrying out amphiphilic polymer assembly and modification on the obtained small-sized platinum nanocrystals by adopting a film dispersion method or an emulsified solvent evaporation method so as to obtain the platinum nanocrystal composite nanomaterial. The invention also relates to the platinum nanocrystal composite nanomaterial. The invention further relates to the platinum nanocrystal composite nanomaterial, which has the characteristics that the platinum nanocrystal composite nanomaterial has good anti-tumor activity, and not only can overcome drug resistance in tumor, but also has good biosecurity for normal tissues.

Description

technical field [0001] The invention relates to the field of preparation of platinum nanocrystal materials, in particular to a preparation method and product of platinum nanocrystal composite nanomaterials. Background technique [0002] At present, despite the continuous improvement of domestic and foreign medical treatment, malignant tumors still seriously threaten the safety of human life. Authoritative organizations such as the World Health Organization (WHO) have released statistical data. Among various malignant tumors such as liver, lung, esophagus, and stomach, China ranks first in the world in terms of new cases and deaths. [0003] Since it was approved by the US FDA in 1978, cisplatin has been widely used in the treatment of various tumors such as head and neck cancer, ovarian cancer, testicular cancer, bladder cancer, lung cancer and colorectal cancer. Due to the low concentration of chloride ions in cells, after cisplatin enters cells, its ligand chlorine will b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/18A61K47/10A61K47/36A61K47/42A61K47/22A61K33/24A61P35/00
CPCA61K9/5123A61K9/5146A61K9/5161A61K9/5169A61K33/24
Inventor 凌代舜李方园胡希
Owner ZHEJIANG UNIV
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