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Pharmaceutical composition and application of pharmaceutical composition in preparation of medicine for resisting prostate cancer

A composition and drug technology, applied in the preparation of anti-prostate cancer drugs, in the field of pharmaceutical compositions, can solve the problems of reducing the polymerization rate of microtubules, reducing the sensitivity and drug resistance of tumor cells to paclitaxel, and achieving significant growth and Proliferation inhibition, clinical dose reduction, and survival reduction effects

Inactive Publication Date: 2018-11-09
GUANGDONG FOOD & DRUG VOCATIONAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, studies have found that docetaxel can antagonize the microtubule stabilization effect of paclitaxel and reduce the sensitivity of tumor cells to paclitaxel in the overexpression of α and β tubulin, the mutation of tubulin and the post-translational modification of tubulin. resistance, and can antagonize paclitaxel-induced polymerization, reduce the rate of microtubule polymerization, and lead to drug resistance

Method used

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  • Pharmaceutical composition and application of pharmaceutical composition in preparation of medicine for resisting prostate cancer
  • Pharmaceutical composition and application of pharmaceutical composition in preparation of medicine for resisting prostate cancer
  • Pharmaceutical composition and application of pharmaceutical composition in preparation of medicine for resisting prostate cancer

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Embodiment 1

[0045] A pharmaceutical composition for synergistic anti-prostate cancer, containing 10-200 parts of curcumin analogue E, 1 part of docetaxel, and 3600 parts of microcrystalline cellulose in molar quantities, fully mixed and filled with 1000 capsules

Embodiment 2

[0047] A pharmaceutical composition for synergistic anti-prostate cancer, comprising 10-100 parts of curcumin analogue E, 1 part of docetaxel, and 2850 parts of microcrystalline cellulose according to the molar measurement. After thorough mixing, 100 capsules are filled.

Embodiment 3

[0049] A pharmaceutical composition for synergistic anti-prostate cancer, containing 10-50 parts of curcumin analogue E, 1 part of docetaxel, and 7600 parts of lactose according to molar measurement. After mixing evenly, add 10% starch made from 5000 parts of starch slurry for spray granulation. Then add 800 parts of magnesium stearate and 3000 parts of PVP, after mixing evenly, tableting is made into 2000 pieces.

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Abstract

The invention discloses a pharmaceutical composition and application of the pharmaceutical composition in the preparation of a medicine for resisting prostate cancer. The pharmaceutical composition contains active components and pharmaceutically acceptable excipients. The active components are composed of docetaxel and a curcumin analog (3E,5E)-3,5-bis(3,4,5-trimethoxybenzylidene)tetrahydropyrane-4-ketone. Preferably, molar ratio of the curcumin analog (3E,5E)-3,5-bis(3,4,5-trimethoxybenzylidene)tetrahydropyrane-4-ketone to docetaxel in the pharmaceutical composition is (10-350): 1. With the combination of the curcumin analog and docetaxel, the product has very obvious effect on cell survival rate of prostate cancer cells, reduces survival rate of prostate cancer cells to a great extent, and remarkably reduces rate of cell migration. It shows that the drug combination has a remarkable effect of inhibiting cell growth and proliferation of prostatic cancer PC-3 cells.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a medicine composition and its application in preparing anti-prostate cancer medicines. Background technique [0002] Cancer is a malignant disease that seriously threatens human health and is one of the main "killers" of human death. Prostate cancer is a malignant tumor that occurs in the prostate tissue of men. In recent years, with the aging population in my country, its incidence has shown a rapid upward trend. [0003] The current treatment methods for prostate cancer mainly include radical surgical resection, radiation therapy, endocrine therapy and chemotherapy. However, when single drug therapy is used, although increasing the dose can improve the curative effect, it is accompanied by an increase in toxic and side effects. And it has the characteristics of strong tissue infiltration and easy early metastasis during treatment. At the time of clinical diagnosis, most ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/351A61K31/337A61P35/00A61P13/08
CPCA61K31/337A61K31/351A61P13/08A61P35/00A61K2300/00
Inventor 周代营
Owner GUANGDONG FOOD & DRUG VOCATIONAL COLLEGE
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