Polypeptide segment diagnosis model and application thereof in prediction of myeloblastoma metastasis risk

A technology of medulloblastoma and peptides, which is applied in the diagnostic model of polypeptide segments and its application in predicting the risk of medulloblastoma metastasis, can solve the problem that differential proteins cannot be found, quantitative analysis stability and sensitivity decline, etc. question
CN112083168APending Publication Date: 2020-12-15AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
Publication Date
2020-12-15

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Abstract

The invention belongs to the technical field of clinical tumor diagnosis, and particularly relates to a model and a prediction kit for predicting whether cerebrospinal fluid peptide fragments of a patient suffering from myeloblastoma are transferred or not in the future according to the change of the components of the cerebrospinal fluid peptide fragments. The method is applied to prediction of myeloblastoma metastasis, the sensitivity of the method is 70.8%, the specificity of the method is 100%, and the AUC value of the method is 0.9619. The method not only can guide tumor staging, but alsocan adjust the postoperative chemotherapy dosage according to the patient metastasis possibility and improve the patient prognosis. And a basis is provided for searching a sensitive and specific medulloblastoma cerebrospinal fluid marker.
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Description

technical field

[0001] The invention belongs to the field of tumor diagnosis and relates to a novel polypeptide segment medulloblastoma metastasis prediction kit. The kit detects 75 peptide segments in the cerebrospinal fluid and compares them with the cerebrospinal fluid after the initial operation. The method is applied to The prediction of medulloblastoma metastasis can not only guide tumor staging, but also adjust the dose of postoperative chemotherapy according to the possibility of patient metastasis, so as to improve the prognosis of patients. And provide a basis for finding sensitive and specific markers of medulloblastoma in cerebrospinal fluid. Background technique

[0002] Medulloblastoma is the most common malignant brain tumor in children, accounting for about 20% of childhood tumors. The prognosis of adults is also very poor. Medulloblastoma is a serious brain disease that endangers people's health. In 2016, WHO classified medulloblastoma into different molecu...

Claims

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