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Psoriasis animal model and construction method and application thereof

A construction method and animal model technology, applied in the direction of animal husbandry, etc., can solve the problem of less animal models of psoriasis, and achieve the effect of good clinical symptom simulation.

Inactive Publication Date: 2020-12-29
澎立生物医药技术(上海)股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, the development and selection of psoriasis animal models in the prior art is still relatively small, because the development of a psoriasis animal model with high clinical symptom simulation is of great significance for screening candidate drugs for psoriasis treatment

Method used

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  • Psoriasis animal model and construction method and application thereof
  • Psoriasis animal model and construction method and application thereof
  • Psoriasis animal model and construction method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] In this embodiment, 30 female Lewis rats at the age of 5-7 weeks were divided into 3 groups on average according to body weight, namely control group, model group and drug administration group, with 10 rats in each group.

[0050] Among them, the three groups of rats all used a razor to shave the back skin, and the control group only applied a blank cream base without imiquimod on the back; the model group and the treatment group applied 5% imiquimod on the back. Cream, the application amount is 1500mg / kg, and the day of application of imiquimod cream is recorded as day 0.

[0051] From the 0th day, the control group and the model group were given biological saline control, and the treatment group was given dexamethasone 0.2 mg / kg (the solvent was biological saline), and the administration methods were intraperitoneal injection.

Embodiment 2

[0053] In this example, a psoriasis model was constructed. The difference between its construction method and the model group construction method in Example 1 is that 5-7 week old female Lewis rats were replaced by 5-7 week old female SD rats. All other conditions remain unchanged. Female SD rats whose backs were only smeared with a blank cream base without imiquimod were defined as the normal group, with 10 rats in each group.

Embodiment 3

[0055] In this example, a psoriasis model was constructed. The difference between its construction method and the model group construction method in Example 1 is that 5-7 week old female Lewis rats were replaced by 5-7 week old female Wistar rats. All other conditions remain unchanged. Female Wistar rats whose backs were only smeared with a blank cream base without imiquimod were defined as the normal group, with 10 rats in each group.

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Abstract

The invention relates to a psoriasis animal model and a construction method and application thereof. The construction method includes the step of carrying out imiquimod administration on the surface of animal skin to obtain the psoriasis animal model. The psoriasis animal model and the construction method and application thereof are used for animal skin for the first time to construct the psoriasis animal model; the psoriasis animal model is similar to a human psoriasis patient, and skin lesion symptoms of an administration part of the psoriasis animal model also comprise red inflammatory plaques with clear local boundaries of the skin, papules, squamous scurf or a layer of light red shiny semitransparent film and the like; after being scratched, small punctiform bleeding occurs; and the performance is highly similar to the performance of the patient, so that good clinical symptom simulation is achieved.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to an animal model of psoriasis and its construction method and application, in particular to an animal model capable of well simulating human psoriasis lesions, its construction method and application. Background technique [0002] Psoriasis is a relatively representative chronic skin disease, most of which will last for 10-20 years after the onset, even if it can temporarily improve after treatment, it must live with the risk of possible recurrence throughout the life. Psoriasis is characterized by erythematous skin lesions covered with well-defined, silvery-white scales, mainly on the elbows, knees, buttocks, scalp, etc. that are more irritated. In addition, psoriasis is often accompanied by multiple complications. Among them, psoriatic arthritis is the specific arthritis produced by psoriasis patients. This kind of psoriasis has no way to directly prevent the onset of ...

Claims

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Application Information

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IPC IPC(8): A01K67/02
CPCA01K67/02A01K2227/105A01K2267/03
Inventor 杨楠付云峰陈洁袁媛成艳段继峰
Owner 澎立生物医药技术(上海)股份有限公司
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