Multi-time-sequence intestinal flora data analysis process control method

A technology for intestinal flora and data analysis, applied in the field of biological analysis, to achieve the effect of wide application, improving scientific research work efficiency and reducing scientific research cost

Active Publication Date: 2020-12-29
康美华大基因技术有限公司
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Therefore, it brings challenges and difficulties to scientific researchers, especially those who do not understand data analysis

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  • Multi-time-sequence intestinal flora data analysis process control method
  • Multi-time-sequence intestinal flora data analysis process control method
  • Multi-time-sequence intestinal flora data analysis process control method

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Embodiment 1

[0037] Such as figure 1 As shown, the present invention provides a preferred embodiment, a method for detecting bacterial flora interaction based on human intestinal time series metagenomic data, comprising the following steps:

[0038] In this example, intestinal feces from a certain individual collected continuously at 4 time points are used as samples for illustration:

[0039] Step 1) Obtain the intestinal flora information of each sample and the corresponding basic information of the human body.

[0040]Among them, the intestinal flora information of the sample is the sequence information of the intestinal flora obtained by DNA extraction from the stool sample, library construction and sequencing. Preferably, this embodiment uses the Biobakery analysis process to perform quality control and species annotation on the sequence information of the flora obtained by sequencing. The quality control process includes filtering low-quality sequences, removing host contamination ...

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Abstract

The invention discloses a multi-time-sequence intestinal flora data analysis process control method. The analysis process mainly comprises the following stages: sample acquisition, intestinal flora data preprocessing, diversity analysis, (sequential sequence) clustering analysis, correlation analysis, bacterial colony interaction network construction and single strain change trend (sequence) prediction. A user inputs a file and corresponding parameters according to the requirements of a process file, and the system automatically analyzes data and outputs the corresponding file and a visualization result. Scientific researchers, including researchers who do not understand data analysis, can efficiently complete a set of standardized intestinal flora data analysis process based on a time sequence, and a final result is obtained. Therefore, the purposes of improving scientific research work efficiency and reducing scientific research cost are achieved.

Description

technical field [0001] The invention relates to the technical field of biological analysis, in particular to a multi-time series intestinal flora data analysis flow control method. Background technique [0002] More and more researchers have found that gut microbes are closely related to human health. The occurrence and development of many diseases, such as inflammatory bowel disease, cancer, obesity, diabetes, allergies and rheumatic immune diseases, have been found to be closely related to the dysbiosis caused by the abnormal composition of intestinal flora. Although more and more evidences have found that the intestinal flora is related to human health, due to the many factors affecting the intestinal flora, the reproducibility of the research results on the intestinal flora is not good, and the level of evidence is low. In order to enhance the credibility of the evidence, more and more longitudinal research designs are applied to the study of gut microbiota. [0003] H...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B30/00G16B40/00G16B45/00G16H50/30
CPCG16B30/00G16B40/00G16B45/00G16H50/30
Inventor 邓煜盛韩丽娟周勇
Owner 康美华大基因技术有限公司
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