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Polysaccharide composition for inhibiting TRPV1 pathway as well as preparation method and application of polysaccharide composition

A technology of composition and polysaccharide, which is applied in the field of polysaccharide composition inhibiting TRPV1 pathway and its preparation, can solve problems such as ineffective effect, aggravated allergies, complicated pathogenesis, etc., and achieve the effect of pre-protection and repair of skin nerve barrier

Active Publication Date: 2021-01-08
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex pathogenesis of sensitive skin, the current clinical dermatology mainly uses physical, drug and anti-allergic cosmetics for treatment, but the effect is not obvious. In addition, there are many types of cosmetics, and improper use will aggravate allergies

Method used

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  • Polysaccharide composition for inhibiting TRPV1 pathway as well as preparation method and application of polysaccharide composition
  • Polysaccharide composition for inhibiting TRPV1 pathway as well as preparation method and application of polysaccharide composition
  • Polysaccharide composition for inhibiting TRPV1 pathway as well as preparation method and application of polysaccharide composition

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Experimental program
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Effect test

Embodiment 1-5

[0040]Example 1-5: Polysaccharide composition of the present invention

Embodiment 1

[0042]Take 1g each of the above Tianshan Saussurea polysaccharide, Tremella polysaccharide, Dendrobium polysaccharide and Salvia miltiorrhiza polysaccharide powder, and dissolve it in distilled pure water. After fully stirring and dissolving, an aqueous solution containing Tianshan Saussurea polysaccharide, Tremella polysaccharide and Salvia polysaccharide is obtained. Among them, the final concentration of Tianshan Saussurea polysaccharide, Tremella polysaccharide, Dendrobium polysaccharide, and Salvia miltiorrhiza polysaccharide are each 0.25mg / mL.

Embodiment 2

[0044]Take the above-mentioned Tianshan Saussurea polysaccharide, Tremella polysaccharide, Dendrobium polysaccharide, 0.4g each, and Salvia miltiorrhiza polysaccharide 4g, and dissolve them in distilled pure water. After fully stirring and dissolving, an aqueous solution containing Tianshan Saussurea polysaccharide, Tremella polysaccharide and Salvia polysaccharide is obtained. The final concentrations of Tianshan Saussurea polysaccharide, Tremella polysaccharide, Dendrobium polysaccharide, and Salvia miltiorrhiza polysaccharide were 0.0077mg / mL, 0.0077mg / mL, 0.0077mg / mL, 0.077mg / mL, respectively.

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Abstract

The invention relates to the technical field of medicines and cosmetics, and discloses a polysaccharide composition for inhibiting a TRPV1 pathway as well as a preparation method and application of the polysaccharide composition. The polysaccharide composition comprises saussurea involucrata polysaccharide, tremella polysaccharide, dendrobium polysaccharide and salvia miltiorrhiza polysaccharide,wherein the concentration of the saussurea involucrata polysaccharide is not higher than 0.4 mg / mL, the concentration of the dendrobium polysaccharide is not higher than 0.35 mg / mL, the concentrationof the tremella polysaccharide is not higher than 0.2 mg / mL, and the concentration of the salvia miltiorrhiza polysaccharide is not higher than 0.2 mg / mL. The polysaccharide composition disclosed by the invention can effectively inhibit the expression of the TRPV1 pathway so as to pre-protect and repair a skin nerve barrier, and can be used in preparation of related cosmetics and medicines for preventing and treating skin allergy.

Description

Technical field[0001]The invention relates to the technical field of medicines and cosmetics, in particular to a polysaccharide composition that inhibits the TRPV1 pathway, and a preparation method and application thereof.Background technique[0002]With the rapid development of social economy, the living standards of residents continue to improve, environmental pollution, life pressure and other factors have caused a series of skin problems, such as sensitive skin. According to incomplete statistics, there are more and more people with sensitive skin in the world, of which 38% are men and 61% are women. Environmental pollution and excessive use of cosmetics have gradually weakened the body's resistance to foreign object stimulation, and skin allergies and irritation have become more frequent. Common symptoms of skin allergies are mainly redness and itching, and may also be accompanied by blisters, swelling, dryness, and exudation and liquefaction. The specific symptoms vary from pers...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P17/00A61P37/08A61K8/73A61Q19/00C08B37/00
CPCA61K8/73A61K31/715A61K2800/5922A61Q19/005A61P17/00A61P37/08C08B37/0003C08B37/006A61K2300/00
Inventor 杨凯业李莉楠刘光荣杜志云彭奕林丽
Owner INFINITUS (CHINA) CO LTD
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