Method for analyzing anti-glandular cystitis action mechanism of pachymaran based on network pharmacology

A technology of network pharmacology and pachymansin, applied in the field of biomedicine, to achieve the effects of narrowing the scope of research and development, enriching development and industrialization, and improving efficiency

Pending Publication Date: 2021-01-08
NANNING SECOND PEOPLES HOSPITAL
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  • Method for analyzing anti-glandular cystitis action mechanism of pachymaran based on network pharmacology
  • Method for analyzing anti-glandular cystitis action mechanism of pachymaran based on network pharmacology
  • Method for analyzing anti-glandular cystitis action mechanism of pachymaran based on network pharmacology

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[0034] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further illustrated and described below through specific embodiments in conjunction with the accompanying drawings.

[0035] 1. Method for analyzing the mechanism of action of pachymansan against cystitis glandularis based on network pharmacology

[0036] 1.1 Poria cocos polysaccharide target screening

[0037] Using "pachyman" as the keyword to search the TCMSP database, the structural formula of pachyman was obtained. Swiss TargetPrediction, HITPICK database and BATMAN database respectively input the SMILE code and IMCHI code corresponding to the structural formula to find the target of pachyranan. Among them, SMILE code and IMCHI code were converted by ChemDraw software, and the target screening range of BATMAN database was score cutoff>20, P<0.05. A total of 4 databases (TCMSP, SwissTarget Prediction, BATMAN, HITPICK database) were applied...

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Abstract

The invention belongs to the field of biomedicine, discloses a method for analyzing an anti-glandular cystitis action mechanism of pachymaran based on network pharmacology, and reports detailed targets and specific pharmacological mechanisms of pachymaran for preventing and treating glandular cystitis for the first time. The method comprises the following main points: obtaining a pachymaran pharmacological target and a glandular cystitis pathogen target through online database analysis of TCMSP, DisGeNET and the like; taking an intersection of the pachymaran and the glandular cystitis target to obtain a drug disease intersection target gene target, and constructing a related protein interaction network to screen a core target; further performing gene ontology GO biological process and KEGGpathway enrichment analysis on the core target by utilizing the R language related packet; and finally, constructing a drug target gene ontology functional pathway disease visualization diagram for deep analysis of a treatment mechanism. The method provided by the invention provides a new idea for explaining a research mechanism of pachymaran for exerting glandular cystitis resistance, and also provides an early-stage research basis for clinical application of pachymaran in glandular cystitis.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a method for analyzing the action mechanism of pachymanan against cystitis glandularis based on network pharmacology. Background technique [0002] Cystitis glandularis (GC) generally refers to lesions and inflammation of the bladder and its glands [1]. During clinical observation, patients can be found to have pathological features such as hematuria, stones, and urethral pain [2]. The pathogenesis of cystitis glandularis is currently unknown, and the resulting infectious bladder injury and secondary inflammation are the main reasons for the further exacerbation of the disease [3]. Clinical identification of patients with early cystitis glandularis is deficient, as is accurate biochemical screening for the disease [4]. In addition, there are limited options for the treatment of cystitis glandularis. Anti-infective and anti-inflammatory drugs are commonly used for intravesical infusio...

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Application Information

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IPC IPC(8): G16H70/40G16B5/00
CPCG16H70/40G16B5/00
Inventor 吴咖颜新卢文胜
Owner NANNING SECOND PEOPLES HOSPITAL
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