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Application of sakuranetin in hair loss prevention and hair growth

A technology of sakura element and hair loss, applied in the field of medicine, compound and its preparation

Inactive Publication Date: 2021-01-12
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no literature publicly reporting the application of sakura element in hair loss and hair growth

Method used

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  • Application of sakuranetin in hair loss prevention and hair growth
  • Application of sakuranetin in hair loss prevention and hair growth
  • Application of sakuranetin in hair loss prevention and hair growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Curative effect evaluation experiment of sakura element on natural hair growth model of C57BL / 6 mice

[0039] 1. Experimental animals

[0040] The experimental animals were male C57BL / J6, 8 weeks old, weighing 18-20 g, purchased from the Comparative Medical Center of Yangzhou University. C57BL / 6 mice were reared under normal conditions, temperature 25±2°C, humidity 50%-70%, light and dark alternately for 12 hours, free to eat and drink, and change the corncob litter every two days until they adapt The experiments were started after 7 days in the rearing environment.

[0041] 2. Drug configuration

[0042] 4% chloral hydrate: 0.4g of chloral hydrate was dissolved in 10ml of normal saline, vortex centrifuged until completely dissolved, and prepared into 4% chloral hydrate solution.

[0043] 2.1 2.5% (O / W) sakurain cream for external use, made from the following raw materials:

[0044]400 parts by weight of sakurain, 1000 parts by weight of stearic acid, 200...

Embodiment 2

[0058] Example 2: Curative effect evaluation experiment of sakura element on C57BL / 6 mouse chemotherapy hair loss model

[0059] 1. Experimental animals

[0060] The experimental animals were male C57BL / J6, 8 weeks old, weighing 18-20 g, purchased from the Comparative Medical Center of Yangzhou University. C57BL / 6 mice were reared under normal conditions, temperature 25±2°C, humidity 50%-70%, light and dark alternately for 12 hours, free to eat and drink, change corncob bedding every two days, and wait for them to adapt The experiments were started after 7 days in the rearing environment.

[0061] 2. Drug configuration

[0062] The configuration of 4% chloral hydrate is the same as above.

[0063] The configuration of the cherry blossom ointment is the same as above.

[0064] The configuration of sakurain oral suspension is the same as above.

[0065] Cyclophosphamide for injection: Dissolve 0.2g cyclophosphamide in 20ml normal saline, vortex centrifuge until completely d...

Embodiment 3

[0078] Example 3: Curative Effect Evaluation Experiment of Cherry Blossom on C57BL / 6 Mouse Androgenetic Alopecia Model 1. Experimental Animals

[0079] The experimental animal is C57BL / J6, 8 weeks old, weighing 18-20g, purchased from the Comparative Medical Center of Yangzhou University. C57BL / 6 mice were reared under normal conditions, temperature 25±2°C, humidity 50%-70%, light and dark alternately for 12 hours, free to eat and drink, change corncob bedding every two days, and wait for them to adapt The experiments were started after 7 days in the rearing environment.

[0080] 2. Drug configuration

[0081] The configuration of 4% chloral hydrate is the same as above.

[0082] The configuration of the cherry blossom ointment is the same as above.

[0083] The configuration of sakurain oral suspension is the same as above.

[0084] Testosterone propionate injection (1mL: 25mg, Guangzhou Baiyunshan Mingxing Pharmaceutical Co., Ltd.), diluted with edible oil to 1mg / ml. The...

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PUM

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Abstract

The invention provides an application of sakuranetin and physiologically acceptable salt or solvate thereof in preparation of a skin application composition and a further application of the skin application composition in pharmaceutical preparations, cosmetics, care products and beauty products. The skin application composition and a further applied preparation can comprehensively and effectivelyaim at various reasons of alopecia, so that the metabolic status of a demand object can be better balanced, and the mental state of the demand object can be adjusted to achieve better treatment and nursing synergistic effects; and the sakuranetin is high in safety of active ingredients and small in toxic and side effects, so that the sakuranetin has a wide application prospect in the fields of thepharmaceutical preparations, the cosmetics, the nursing products, the beauty products and the like.

Description

technical field [0001] The invention belongs to the field of compounds and preparations thereof, and specifically relates to the use of sakurain in the preparation of anti-hair loss and hair growth preparations, and its further application in the fields of medicine, cosmetics, care products, beauty products and the like. Background technique [0002] Hair is a special derived structure of the skin and is also a characteristic of mammals, which plays an important role in aesthetics and maintenance of body temperature. Alopecia is a clinically common skin disease characterized by hair loss, which affects up to 70% and 40% of males and females. Hair loss not only negatively affects patient image and self-esteem, but also robs cancer patients of their right to privacy. Although a variety of strategies for the treatment of hair loss have been clinically applied, there is still a lack of efficient and safe treatments. In view of this, studying its mechanism and developing safe a...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P17/14A61K8/49A61Q7/00
CPCA61K31/352A61P17/14A61K8/498A61Q7/00
Inventor 吴亮陈佳敏冯陈杰蔡磊蔡溪云弋吴舒婷董昊郝园园刘宙刘玉琳朱俊霖徐佳怡曹毅眀吴晓明
Owner CHINA PHARM UNIV
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