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Application of rebamipide to alopecia prevention and hair growth

A technique for rebamipide and hair loss, which is applied in the field of compounds and their preparations, and medicines, and can solve problems such as rebamipide that have not yet been publicly reported in the literature

Active Publication Date: 2021-03-16
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no literature publicly reporting the application of rebamipide in hair loss and hair growth

Method used

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  • Application of rebamipide to alopecia prevention and hair growth
  • Application of rebamipide to alopecia prevention and hair growth
  • Application of rebamipide to alopecia prevention and hair growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: The curative effect evaluation experiment of rebamipide on the natural hair growth model of C57BL / 6 mice

[0039] 1. Experimental animals

[0040]The experimental animals were male C57BL / J6, 8 weeks old, weighing 18-20 g, purchased from the Comparative Medical Center of Yangzhou University. C57BL / 6 mice were reared under normal conditions, temperature 25±2°C, humidity 50%-70%, light and dark alternately for 12 hours, free to eat and drink, change corncob bedding every two days, and wait for them to adapt The experiments were started after 7 days in the rearing environment.

[0041] 2. Drug configuration

[0042] 4% chloral hydrate: 0.4g of chloral hydrate was dissolved in 10ml of normal saline, vortex centrifuged until completely dissolved, and prepared into 4% chloral hydrate solution.

[0043] 2.1 4% (O / W) rebamipide cream for external use, made from the following raw materials:

[0044] 400 parts by weight of rebamipide, 1000 parts by weight of stearic...

Embodiment 2

[0058] Example 2: The curative effect evaluation experiment of rebamipide on C57BL / 6 mouse chemotherapy alopecia model

[0059] 1. Experimental animals

[0060] The experimental animals were male C57BL / J6, 8 weeks old, weighing 18-20 g, purchased from the Comparative Medical Center of Yangzhou University. C57BL / 6 mice were reared under normal conditions, temperature 25±2°C, humidity 50%-70%, light and dark alternately for 12 hours, free to eat and drink, change corncob bedding every two days, and wait for them to adapt The experiments were started after 7 days in the rearing environment.

[0061] 2. Drug configuration

[0062] The configuration of 4% chloral hydrate is the same as above.

[0063] The configuration of rebamipide ointment is the same as above.

[0064] The configuration of rebamipide oral suspension is the same as above.

[0065] Cyclophosphamide for injection: Dissolve 0.2g cyclophosphamide in 20ml normal saline, vortex centrifuge until completely dissolve...

Embodiment 3

[0078] Example 3: The curative effect evaluation experiment of rebamipide on C57BL / 6 mouse androgenetic alopecia model

[0079] 1. Experimental animals

[0080] The experimental animal is C57BL / J6, 8 weeks old, weighing 18-20g, purchased from the Comparative Medical Center of Yangzhou University. C57BL / 6 mice were reared under normal conditions, temperature 25±2°C, humidity 50%-70%, light and dark alternately for 12 hours, free to eat and drink, change corncob bedding every two days, and wait for them to adapt The experiments were started after 7 days in the rearing environment.

[0081] 2. Drug configuration

[0082] The configuration of 4% chloral hydrate is the same as above.

[0083] The configuration of rebamipide ointment is the same as above.

[0084] The configuration of rebamipide oral suspension is the same as above.

[0085] Testosterone propionate injection (1mL: 25mg, Guangzhou Baiyunshan Mingxing Pharmaceutical Co., Ltd.), diluted with edible oil to 1mg / ml. ...

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PUM

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Abstract

The invention provides application of rebamipide and physiologically acceptable salt or solvate thereof to preparation of a skin application composition and further application of the skin applicationcomposition to pharmaceutical preparations, cosmetics, nursing products and beauty products. The skin application composition and a further applied preparation can comprehensively and effectively aimat various reasons of alopecia, so that the metabolic conditions of a demand object can be better balanced; the mental state of the demand object is adjusted to achieve the better treatment and nursing synergistic effect; and the rebamipide is high inactive ingredient safety and small in toxic and side effects, so that the rebamipide has a wide application prospect in the fields of the pharmaceutical preparations, the cosmetics, the nursing products, the beauty products and the like.

Description

technical field [0001] The invention belongs to the field of compounds and preparations thereof, and specifically relates to the use of rebamipide in the preparation of anti-hair loss and hair growth preparations, and its further application in the fields of medicine, cosmetics, nursing products, beauty products and the like. Background technique [0002] Alopecia is the phenomenon of hair falling out. The process of normal people's new city metabolism is also accompanied by the shedding and regeneration of hair, which belongs to the normal metabolic phenomenon of organisms. The hair that falls out normally is the hair in the catagen and telogen phase. Since the hair entering the catagen and the newly entering the growth phase are constantly in a dynamic balance, it can maintain a normal amount of hair. However, for pathological alopecia, it is the phenomenon of abnormal hair loss caused by various reasons, such as excessive stress, staying up late, or endocrine disorders. ...

Claims

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Application Information

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IPC IPC(8): A61K31/438A61P17/14A61P37/02A61P17/00A61K8/49A61Q7/00
CPCA61K31/438A61P17/14A61P37/02A61P17/00A61K8/4926A61Q7/00
Inventor 吴亮蔡磊钱洪发冯陈杰蔡溪云弋吴舒婷董昊郝园园陈佳敏刘宙吴晓明
Owner CHINA PHARM UNIV
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