A prognostic diagnostic marker claudin21 for ovarian cancer and its application

A diagnostic marker, ovarian cancer technology, applied in the field of clinical analysis, can solve the problems of no other family members, no specific Claudin21 related to the prognosis of gynecological tumors, etc.
CN112229999BActive Publication Date: 2022-04-22ZHEJIANG CANCER HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG CANCER HOSPITAL
Publication Date
2022-04-22

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Abstract

The present invention is a prognostic diagnostic marker Claudin21 for ovarian cancer and its application. For the first time, it is found that the expression level of the ovarian cancer drug resistance marker Claudin21 is related to the prognosis of ovarian cancer, specifically the progression-free survival and overall survival when Claudin21 is highly expressed. Among the medium prognostic indicators, ovarian cancer cases show poor prognosis, that is, the discovery of the present invention provides prognosis hints for clinical treatment of ovarian cancer including chemotherapy and surgical treatment.
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Description

technical field

[0001] The present invention belongs to the field of molecular biology, specifically relates to the field of diagnosis / grading / staging and prognosis of cancer, more specifically, the present invention relates to the field of ovarian cancer. The present invention also relates to the fields of ovarian cancer diagnosis, grading, staging and prognosis including the expression of biomarkers, and also provides related analytical reagents, diagnostic models, test kits and clinical analysis. Background technique

[0002] Ovarian cancer is the gynecological tumor with the highest mortality rate among women in my country. According to the China Cancer Annual Report, there were about 52,100 new patients in 2015, and about 22,500 people died of ovarian cancer in the same year. With the aging population in my country, the incidence of ovarian cancer is increasing year by year, and the age of onset tends to be younger. Globally, the incidence of ovarian cancer ranks third...

Claims

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