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Novel compound and pharmaceutical composition

A compound and composition technology, applied in the field of new compounds and pharmaceutical compositions, can solve problems such as complex components of carrimycin and failure of finished products to meet the component index requirements, and achieve the effect of simple operation

Pending Publication Date: 2021-01-19
SHENYANG FUYANG PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The components of carrimycin are complex, and the extract obtained from the fermentation broth by solvent extraction method contains too much acetyl and propionylspiramycin, so the final product cannot meet the component index requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] 1. Preparation of carrimycin samples

[0062] Culture fermentation:

[0063] (1) Pick a single colony from the preservation slope of the WSJ195 strain for subculture, and then pick a colony with sunken folds in the middle of the surface for secondary subculture activation;

[0064] According to the inoculation amount of 0.1%, inoculate into the primary seed medium for cultivation, control the tank pressure at 0.04MPa, control the tank temperature at 28°C, control the ventilation rate at 1: (1±0.1) v / v / min, and cultivate 48h, obtain the primary seed liquid;

[0065] (2) Inoculate the first-level seed liquid into the second-level seed medium by 20% inoculum amount for cultivation, control the tank pressure to be 0.04±0.01MPa, control the tank temperature to be 28±1°C, and control the ventilation rate to be 1:( 1±0.1)v / v / min, cultivated for 24h to obtain the secondary seed solution;

[0066] (3) Inoculate the secondary seed liquid into the fermenter with an inoculation ...

Embodiment 2

[0164] 1. Preparation of carrimycin samples

[0165] Culture fermentation:

[0166] (1) Pick a single colony from the preservation slope of the WSJ195 strain for subculture, and then pick a colony with sunken folds in the middle of the surface for secondary subculture activation;

[0167] According to the inoculation amount of 0.1%, inoculate into the primary seed medium for cultivation, control the tank pressure at 0.04±0.01MPa, control the tank temperature at 28±1°C, and control the ventilation rate at 1:(1±0.1)v / v / min, cultivated for 49h, and obtained the first-grade seed solution;

[0168](2) Inoculate the first-level seed liquid into the second-level seed medium by 20% inoculum amount for cultivation, control the tank pressure to be 0.04±0.01MPa, control the tank temperature to be 28±1°C, and control the ventilation rate to be 1:( 1±0.1)v / v / min, cultured for 25h, to obtain the secondary seed liquid;

[0169] (3) Inoculate the secondary seed liquid into the fermenter w...

Embodiment 3

[0178] 1. Preparation of carrimycin samples

[0179] Culture fermentation:

[0180] (1) Pick a single colony from the preservation slope of the WSJ195 strain for subculture, and then pick a colony with sunken folds in the middle of the surface for secondary subculture activation;

[0181] According to the inoculation amount of 0.1%, inoculate into the primary seed medium for cultivation, control the tank pressure at 0.04±0.01MPa, control the tank temperature at 28±1°C, and control the ventilation rate at 1:(1±0.1)v / v / min, cultivated for 45h to obtain the primary seed solution;

[0182] (2) Inoculate the first-level seed liquid into the second-level seed medium by 20% inoculum amount for cultivation, control the tank pressure to be 0.04±0.01MPa, control the tank temperature to be 28±1°C, and control the ventilation rate to be 1:( 1±0.1)v / v / min, cultivated for 24h to obtain the secondary seed solution;

[0183] (3) Inoculate the secondary seed liquid into the fermenter with ...

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Abstract

The invention belongs to the field of medicinal chemistry, and particularly relates to a novel compound and a pharmaceutical composition. The structural formula of the novel compound is shown as a formula (1). The method is simple to operate, and the novel compound is obtained by separating and purifying kelimycin through a novel separation and purification method. It is surprisingly found that when a small amount of the novel compound is contained in the kelimycin composition, a synergistic effect is generated, and a better antibacterial effect is achieved.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and in particular relates to a new compound and a pharmaceutical composition. Background technique [0002] Kelimycin (Kelimycin), also known as Bitespiramycin (Bitespiramycin) and Shengjimycin (Shengjimycin), is produced by the Institute of Biotechnology of the Chinese Academy of Medical Sciences and the applicant through transgenic technology to produce carbamycin. The 4”-o-acyl-transferase group (4”-o-acyl-transferase) of the spiramycin was cloned into the spiramycin-producing strain to acylate the spiramycin 4”-OH, and the isovaleryl side chain was added at the 4” position A new type of antibiotic formed with the 4” isovaleryl spiramycin as the main component. [0003] Corimycin is composed of a variety of spiramycin derivatives, the structural formula is shown in formula (2), and the total content of the main active ingredient isovalerylspiramycin (I+II+III) is not less than 60%, 4" The ...

Claims

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Application Information

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IPC IPC(8): C07H17/08C07H1/06A61K31/7048A61P31/04A61P11/00A61P13/00C12P19/62
CPCC07H17/08C07H1/06A61P31/04A61P11/00A61P13/00C12P19/62A61K31/7048A61P31/10A61P31/00C07H1/08
Inventor 梁鑫淼刘艳芳夏明钰邱桂侠姜勋东
Owner SHENYANG FUYANG PHARM TECH CO LTD