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Application and pharmaceutical composition of chalcone compound in preparation of medicine for treating Alzheimer's disease

A technology for Alzheimer's disease and compounds, which is applied in the field of chalcone compound drugs, can solve the problems of low acetylcholinesterase inhibition efficiency and poor treatment effect of Alzheimer's disease, and achieve strong acetylcholinesterase inhibitory activity , the effect of good application prospects

Active Publication Date: 2022-01-04
SHANDONG ANALYSIS & TEST CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inventors found that the existing drugs have low inhibitory efficiency to acetylcholinesterase, and thus have poor therapeutic effect on Alzheimer's disease

Method used

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  • Application and pharmaceutical composition of chalcone compound in preparation of medicine for treating Alzheimer's disease
  • Application and pharmaceutical composition of chalcone compound in preparation of medicine for treating Alzheimer's disease
  • Application and pharmaceutical composition of chalcone compound in preparation of medicine for treating Alzheimer's disease

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Experimental program
Comparison scheme
Effect test

Embodiment

[0043] experiment apparatus

[0044] Nicolet-510P infrared spectrometer (USA), v max in cm -1 The unit is Bruker AMX-400 nuclear magnetic resonance instrument, TMS is the internal standard, the chemical shift is expressed in δ, and the coupling constant is expressed in J.

[0045] Extraction and Separation Methods

[0046] 3.4kg of ranunculus thorns were crushed, leached with 10L ethanol at room temperature, the filtrate was filtered, and concentrated under reduced pressure to obtain 6.5g of the total extract. The total extract was separated by silica gel column chromatography, and the gradient elution of the n-hexane / ethyl acetate system was followed by a mixture of n-hexane / ethyl acetate volume ratios of 10:90, 7.5:92.5 and 5:95. Solvent was eluted to obtain 8 components (F1-8), wherein, component F3 (120 mg) was subjected to repeated silica gel chromatography (1.8:8.2, v / v) in the n-hexane / ethyl acetate system to obtain 4- benzyloxylonchocarpin (new chalcone compound, 7...

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Abstract

The invention discloses the application and pharmaceutical composition of a chalcone compound in the preparation of drugs for treating Alzheimer's disease. The structural formula of the chalcone compound is as follows: wherein, R=Bn,

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical application of chalcone compounds, and in particular relates to the application and pharmaceutical composition of chalcone compounds in the preparation of medicines for treating Alzheimer's disease. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Alzheimer's disease is a neurodegenerative disease with insidious onset and progressive development. It mainly occurs in the elderly, and its prevalence increases significantly with age. Patients mainly present with cognitive or behavioral (neuropsychiatric) changes such as memory. Alzheimer's disease is constantly developing: mild symptoms mai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K31/353A61P25/28
CPCA61K31/352A61K31/353A61P25/28A61K2300/00
Inventor 王岱杰希达悦·侯赛因崔莉吕翠伊夫蒂哈尔·阿里张浩张宇娜嘉·恩格尔
Owner SHANDONG ANALYSIS & TEST CENT
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