Bone filling material with long-acting antibacterial function as well as application and preparation method thereof

Abstract

The invention discloses a bone filling material with a long-acting antibacterial function as well as an application and a preparation method thereof, the bone filling material is composed of degradable porous biological ceramic, polylysine salt and polyaspartate, and the polylysine salt and the polyaspartate are loaded in the porous biological ceramic. According to the invention, degradable polylysine salt and polyaspartate with good biocompatibility and broad-spectrum antibacterial performance are loaded into the degradable porous biological ceramic in an opposite charge solution soaking manner, so that the continuous release of the polylysine salt is realized, and a long-acting antibacterial effect is achieved. Meanwhile, the bone filling material disclosed by the invention has a porousstructure, and lysine, aspartic acid, calcium ions and phosphate ions are controllably degraded and released, so that the bone filling material has very high osteogenesis activity, and can be appliedto fracture or bone defect filling for preventing or preventing postoperative bone infection and bone defect filling caused by bone infection fracture or bone infection.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a bone filling material with long-acting antibacterial function and its application and preparation method. Background technique [0002] Human bones can be damaged for various reasons. The treatment of bone defects usually needs to be filled with bone repair materials for repair, and in the process of bone therapy surgery, antibacterial treatment of the wound surface is also required to avoid complications such as bone infection caused by the wound surface and further transformation into severe osteomyelitis. In particular, for the repair of bone defects caused by bone infection, not only bone repair materials need to be filled, but also long-term antibacterial treatment of wounds is required. [0003] The current antibacterial treatment method in the bone surgery process mainly uses antibiotics such as sulfadiazine, iodide, etc. to treat wounds locally, and supple...

AI Technical Summary

Problems solved by technology

After loading polylysine salt and polyaspartic acid salt into degradable porous bioceramics, polylysine salt has broad-spectrum antibacterial ability and good biocompatibility, and polylysine salt and polyaspartate Particate has a very good affinity adsorption-desorption effect on the surface of bioceramics, thereby solving the existing silver-containing bone repair materials due to the toxic side effects of silver and the difficulty of releasing silver, which leads to poor antibacterial effect of silver At the same time, because the porous bioceramic loaded with polylysine salt and polyaspartate has good biocompatibility and long-term broad-spectrum antibacterial function, and the porous ceramic has degradability and porous structure, it can Further releasing the polylysine salt with broad-spectrum antibacterial properties makes the porous bioceramic provided by the present invention have high osteogenic activity

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