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Ionized hydrogel-based artificial nervous tissue engineering material as well as preparation method and application thereof

A technology of artificial nerve and tissue engineering, which is applied in the field of artificial nerve tissue engineering materials to achieve low viscoelasticity, good biological microenvironment, and the effect of promoting regeneration

Active Publication Date: 2021-01-29
AIR FORCE MEDICAL CENT PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, in the early stage of damage repair, how to rebuild the conduction of nerve electrical signals as soon as possible, there is little research attention at present

Method used

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  • Ionized hydrogel-based artificial nervous tissue engineering material as well as preparation method and application thereof
  • Ionized hydrogel-based artificial nervous tissue engineering material as well as preparation method and application thereof
  • Ionized hydrogel-based artificial nervous tissue engineering material as well as preparation method and application thereof

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Embodiment 1

[0031] This embodiment provides a kind of artificial nerve tissue engineering material based on ionic hydrogel, and its preparation process is as follows:

[0032] (1) Add 40mL of 0.9% NaCl solution to the cleaned beaker, and then add 6.14g of acrylamide while stirring, until the solution is clarified;

[0033] (2) Add 0.414g polylysine, stir for 3min, add 0.005g N-N, methylene acrylamide (MBAA), 0.01g ammonium persulfate, stir for 10min; then add 0.05mL N,N,N', N'-Tetramethylethylenediamine, after stirring for 20 minutes, a uniform prepolymer solution is formed;

[0034] (3) Drop the pre-polymerized solution obtained in step (2) into a polytetrafluoroethylene mold, irradiate it under a purple light for 3 hours, take it out, soak it in 0.9% NaCl solution, and wash it on a shaking table for 45 minutes, a total of 3 times.

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Abstract

The invention provides a preparation method of an ionic hydrogel-based artificial nervous tissue engineering material, which comprises the following steps: (1)preparation of a prepolymer solution: byusing acrylamide as a monomer and ammonium persulfate as an initiator, sequentially adding acrylamide, polylysine, N,N '-methylene bisacrylamide, ammonium persulfate and N, N, N ', N'-tetramethylethylenediamine to form the prepolymer solution; and (2)preparation of the hydrogel material: adding the prepolymer solution into a template, and reacting for 3-4 hours under ultraviolet irradiation to form the hydrogel material. The technical problem that in the prior art, a material capable of being effectively applied to nervous system injury reparation does not exist, and particularly a material capable of reconstructing neuroelectric signal conduction in the early stage is solved.

Description

technical field [0001] The invention belongs to the technical field of intelligent bionic materials, and in particular relates to an artificial nerve tissue engineering material based on ionic hydrogel, its preparation method and its application. Background technique [0002] Nervous system is the leading functional regulation system in the human body. It consists of a central part and its peripheral part. The central part includes the brain and spinal cord, and the peripheral part constitutes the peripheral nervous system. At present, millions of people around the world suffer from nervous system injuries. The latest global epidemiological survey in 2015 shows that the incidence of peripheral nerve injuries is as high as 13-23 / 100,000 people. There are about 1 million new cases of peripheral nerve injuries in my country every year. Among them, there are about 300,000 cases of neurological deficits. [0003] There are still great difficulties in the repair of nervous system ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08F283/04C08F220/56C08F222/38C08F4/30C08F2/48A61P25/00A61L27/52A61L27/50A61L27/16A61K47/34A61K9/06
CPCC08J3/075C08F283/04C08F4/30C08F2/48A61L27/52A61L27/50A61L27/16A61K47/34A61K9/06A61P25/00A61L2430/32A61L2300/412C08L51/08C08F220/56C08F222/385
Inventor 周岩王鹏飞张成业曹莹泽赵明月李振吕晓娇卢亚妹
Owner AIR FORCE MEDICAL CENT PLA
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