Ionized hydrogel-based artificial nervous tissue engineering material as well as preparation method and application thereof

Abstract

The invention provides a preparation method of an ionic hydrogel-based artificial nervous tissue engineering material, which comprises the following steps: (1)preparation of a prepolymer solution: byusing acrylamide as a monomer and ammonium persulfate as an initiator, sequentially adding acrylamide, polylysine, N,N '-methylene bisacrylamide, ammonium persulfate and N, N, N ', N'-tetramethylethylenediamine to form the prepolymer solution; and (2)preparation of the hydrogel material: adding the prepolymer solution into a template, and reacting for 3-4 hours under ultraviolet irradiation to form the hydrogel material. The technical problem that in the prior art, a material capable of being effectively applied to nervous system injury reparation does not exist, and particularly a material capable of reconstructing neuroelectric signal conduction in the early stage is solved.

Description

technical field [0001] The invention belongs to the technical field of intelligent bionic materials, and in particular relates to an artificial nerve tissue engineering material based on ionic hydrogel, its preparation method and its application. Background technique [0002] Nervous system is the leading functional regulation system in the human body. It consists of a central part and its peripheral part. The central part includes the brain and spinal cord, and the peripheral part constitutes the peripheral nervous system. At present, millions of people around the world suffer from nervous system injuries. The latest global epidemiological survey in 2015 shows that the incidence of peripheral nerve injuries is as high as 13-23 / 100,000 people. There are about 1 million new cases of peripheral nerve injuries in my country every year. Among them, there are about 300,000 cases of neurological deficits. [0003] There are still great difficulties in the repair of nervous system ...

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