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Peritoneal dialysis solution for preventing and reducing peritoneal fibrosis

A technology of peritoneal dialysis fluid and fibrosis, which is applied in the direction of blood diseases, extracellular fluid diseases, anhydride/acid/halide active ingredients, etc. It can solve the problems of decreased ultrafiltration, failure to achieve therapeutic effect, and weakened dialysis effect. To achieve the effect of increased ultrafiltration function, decreased trend, and enhanced dialysis effect

Inactive Publication Date: 2021-02-02
西安乐析医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Clinically, there are many patients, with the extension of dialysis age, peritoneal fibrosis begins to appear, ultrafiltration decreases, dialysis effect weakens, and the therapeutic effect cannot be achieved

Method used

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  • Peritoneal dialysis solution for preventing and reducing peritoneal fibrosis
  • Peritoneal dialysis solution for preventing and reducing peritoneal fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The peritoneal dialysis solution for preventing and reducing peritoneal fibrosis described in this embodiment is weighed respectively by mass percentage: glucose 15g, sodium chloride 5.38g, calcium chloride 0.26g, magnesium chloride 0.051g, sodium lactate 4.48g, tranexamic acid 5g, water for injection 969.83mL, and the water for injection is divided into two parts of equal mass, which are respectively recorded as No. 1 water for injection and No. 2 water for injection; the glucose, tranexamic acid and No. The sodium chloride, calcium chloride, magnesium chloride, sodium lactate and No. 2 water for injection constitute liquid B; the liquids A and B constitute the peritoneal dialysis liquid.

Embodiment 2

[0024] The peritoneal dialysis solution for preventing and reducing peritoneal fibrosis described in this embodiment is weighed respectively by mass percentage: glucose 15g, sodium chloride 5.38g, calcium chloride 0.26g, magnesium chloride 0.051g, sodium lactate 4.48g, tranexamic acid 0.1g, 974.73mL of water for injection, and divide the water for injection into two parts of equal mass, which are respectively recorded as No. 1 water for injection and No. 2 water for injection; the glucose, tranexamic acid and No. 1 water for injection are composed of liquid A; The sodium chloride, calcium chloride, magnesium chloride, sodium lactate, and No. 2 water for injection are used to form liquid B, and the liquids A and B are used to form the peritoneal dialysis solution.

Embodiment 3

[0026] The peritoneal dialysis solution for preventing and reducing peritoneal fibrosis described in this embodiment is weighed respectively by mass percentage: glucose 15g, sodium chloride 5.38g, calcium chloride 0.26g, magnesium chloride 0.051g, sodium lactate 4.48g, tranexamic acid 1.5g, 973.33mL of water for injection, and divide the water for injection into two parts of equal mass, which are recorded as No. 1 water for injection and No. 2 water for injection; the glucose, tranexamic acid and No. 1 water for injection are composed of liquid A; The sodium chloride, calcium chloride, magnesium chloride, sodium lactate and No. 2 water for injection are used to form liquid B; the liquid A and liquid B are used to form the peritoneal dialysis solution.

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Abstract

The invention belongs to the technical field of peritoneal dialysis, and particularly relates to a peritoneal dialysis solution for preventing and reducing peritoneal fibrosis. The peritoneal dialysissolution is prepared from the following components in percentages by mass: 1.5%-4.25% of glucose, 0.3%-0.6% of sodium chloride, 0.01%-0.03% of calcium chloride, 0.002%-0.006% of magnesium chloride, 0.2%-0.5% of sodium lactate, 0.01%-0.5% of tranexamic acid and the balance of water for injection. The novel peritoneal dialysis solution obtained by long-term research can solve the problem of peritoneal fibrosis caused by long-term use of an existing dialysis solution, so that the tendency of peritoneal fibrosis is reduced, the ultrafiltration function is improved, the dialysis effect is enhanced, the treatment effect is achieved, and the dialysis age of a patient subjected to long-term dialysis can be prolonged.

Description

technical field [0001] The invention belongs to the technical field of peritoneal dialysis, in particular to a peritoneal dialysis solution for preventing and reducing peritoneal fibrosis. Background technique [0002] Our country is a country with a relatively large incidence of chronic kidney disease. According to epidemiological statistics, it is found that the reason is related to the relatively high incidence of diabetes in our country. Secondly, advanced hypertension can also cause renal failure and uremia. The incidence of these two causes The rate has surpassed the original type of nephropathy, and it is the main cause of uremia. [0003] In 2010, there was an epidemiological survey on the number of uremia in our country, and it was believed that the number of people who needed dialysis was about 2 million, and this figure has been adopted throughout the country since then. In 2020, The Lancet published the latest epidemiological survey. We believe that this survey ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61K9/08A61P7/08A61K33/06A61K31/19A61K31/195A61K31/7004
CPCA61K9/08A61K31/19A61K31/195A61K31/7004A61K33/06A61K33/14A61P7/08A61K2300/00
Inventor 李继仁李云峰田景云梁志兴
Owner 西安乐析医疗科技有限公司