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A kind of novel peritoneal dialysis solution and preparation method thereof

A peritoneal dialysis solution and new technology, applied in the field of new peritoneal dialysis solution and its preparation, can solve the problems of failure to achieve therapeutic effect, weakened dialysis effect, and decreased ultrafiltration function, so as to prevent and reduce peritoneal fibrosis and dialysis effect Enhanced, ultra-filtration function increased effect

Active Publication Date: 2021-06-04
西安乐析医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In clinical practice, there are many patients, with the prolongation of dialysis age, peritoneal fibrosis begins to appear, ultrafiltration function declines, dialysis effect weakens, and the therapeutic effect cannot be achieved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0031] In order to prevent and reduce the tendency of peritoneal fibrosis, the present invention provides a new type of peritoneal dialysis solution and its preparation method, which is of great significance for long-term dialysis and can prolong the dialysis age.

[0032] The double-chamber bag of the present invention is a non-PVC double-chamber bag, which is a common non-PVC double-chamber bag in the prior art, and its use method is also a common method in the prior art. Glucose, sodium chloride, calcium chloride, magnesium chloride, sodium lactate, sodium hyaluronate and water for injection described in the present invention are all medical grade.

Embodiment 1

[0034] The novel peritoneal dialysis solution described in this embodiment is composed of A liquid and B liquid:

[0035] Weigh 42.5g of glucose, 5.56g of sodium chloride, 0.26g of calcium chloride, 0.05g of magnesium chloride, 4.48g of sodium lactate, 0.15g of sodium hyaluronate, and 947mL of water for injection, and divide the water for injection into two equal parts, namely 473.5mL each, recorded as No. 1 water for injection and No. 2 water for injection;

[0036] Among them, liquid A is composed of 42.5g of glucose and 473.5 of No. 1 water for injection;

[0037] Liquid B consists of 5.56g sodium chloride, 0.26g calcium chloride, 0.05g magnesium chloride, 4.48g sodium lactate, 0.15g sodium hyaluronate, and 473.5mL of No. 2 water for injection.

[0038] The preparation method of above-mentioned novel peritoneal dialysis fluid, comprises the steps:

[0039](1) Weigh respectively according to the required mass percentage: glucose 42.5g, sodium chloride 5.56g, calcium chlori...

Embodiment 2

[0045] The novel peritoneal dialysis solution described in this embodiment is composed of A liquid and B liquid:

[0046] Weigh 10g of glucose, 6g of sodium chloride, 0.2g of calcium chloride, 0.02g of magnesium chloride, 3.5g of sodium lactate, 0.88g of sodium hyaluronate, and 979.4mL of water for injection, and divide the water for injection into two equal parts. 489.7mL, recorded as No. 1 water for injection and No. 2 water for injection;

[0047] Among them, liquid A is composed of 10g of glucose and 489.7mL of No. 1 water for injection;

[0048] Liquid B consists of 6g sodium chloride, 0.2g calcium chloride, 0.02g magnesium chloride, 3.5g sodium lactate, 0.88g sodium hyaluronate, and 489.7mL of No. 2 water for injection.

[0049] The preparation method of above-mentioned novel peritoneal dialysis fluid, comprises the steps:

[0050] (1) Weigh respectively according to the required mass percentage: glucose 10g, sodium chloride 6g, calcium chloride 0.2g, magnesium chlorid...

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Abstract

The invention belongs to the technical field of peritoneal dialysis, and in particular relates to a novel peritoneal dialysis solution and a preparation method thereof. The novel peritoneal dialysis solution is composed of the following components in mass percentage: glucose 1%-5%, sodium chloride 0.3%-0.6%, calcium chloride 0.01%-0.03%, magnesium chloride 0.002%-0.006%, sodium lactate 0.2% ‑0.5%, sodium hyaluronate 0.01%‑0.1%, and the balance is water for injection. The novel peritoneal dialysis solution obtained through long-term research of the present invention can solve the problem of peritoneal fibrosis caused by the long-term use of the existing dialysis solution, reduce the trend of peritoneal fibrosis, increase the ultrafiltration function, enhance the dialysis effect, and achieve a therapeutic effect. For long-term dialysis Patients are able to extend their age. The novel peritoneal dialysis solution of the present invention adopts a double-chamber bag packaging sterilization process, that is, the glucose solution and the sodium hyaluronate solution are respectively packed in two chambers for sterilization, so as to avoid placing the glucose and sodium hyaluronate solution in the storage process. A slow reaction occurs so that the solution turns yellow, impurities increase and the dialysis effect decreases.

Description

technical field [0001] The invention belongs to the technical field of peritoneal dialysis, and in particular relates to a novel peritoneal dialysis solution and a preparation method thereof. Background technique [0002] Kidney failure Uremia is often treated with dialysis, which removes waste toxins and excess water from the body. Patients who adopt dialysis technology can maintain their lives, and the age of dialysis in western developed countries is as long as more than 20 years. There are two dialysis techniques: one is hemodialysis and the other is peritoneal dialysis. Peritoneal dialysis is a new technology being promoted in our country, which is suitable for our national conditions. This technology is only in the development stage in our country, but compared with hemodialysis, it has the characteristics of home treatment, so it can greatly improve the quality of life of patients, and patients can go to work, work and study like normal people. Since it does not re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/728A61K31/7004A61K33/06A61K31/19
CPCA61K9/08A61K31/19A61K31/7004A61K31/728A61K33/06A61K33/14A61P7/08A61K2300/00
Inventor 李继仁佘佑廷赵峰王森康战国包禧艳
Owner 西安乐析医疗科技有限公司