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Dialysis membrane for hemodialyzer and preparation method thereof

A technology of hemodialysis and dialysis membrane, which is applied in the field of medical devices, can solve the problems of biocompatibility, blood description, hydrophilicity, smoothness and low removal rate, and achieve good surface hydrophilicity and easy availability of raw materials , the effect of high ultrafiltration coefficient

Inactive Publication Date: 2019-02-12
湖南博隽生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These commonly used dialysis membranes have a high clearance rate for medium and large molecule toxins, and have good strength and flexibility, but their biocompatibility, blood-descriptive properties, hydrophilicity, smoothness and removal rate are relatively low

Method used

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  • Dialysis membrane for hemodialyzer and preparation method thereof
  • Dialysis membrane for hemodialyzer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A method for preparing a dialysis membrane for a hemodialyzer, comprising the steps of:

[0032] ⅠDissolve 1kg of 3,4-dihydroxyfuran-2,5-dicarboxylate diethyl ester, 2kg of 4,6-bis(1-adamantyl)-1,3-diglycidyl ether benzene in dimethyl ethylene Add 0.3 kg of sodium carbonate to 10 kg of sulfone, stir and react for 12 hours in a nitrogen atmosphere at 75 ° C, then precipitate in water, then filter the precipitated polymer with suction, and dry it in a vacuum oven at 90 ° C until constant Heavy, obtain adamantyl furyl condensation polymer;

[0033] II Dissolving 1 kg of the adamantyl furanyl polycondensate prepared in step I in 4 kg of N,N-dimethylformamide, vacuum defoaming to obtain a spinning solution, injecting the spinning solution into a spinning solution tank, Adjust the pressure to 3 atmospheres, control the temperature to 70 degrees Celsius, and control the speed of the collection drum to 800 rpm, and then spin to obtain the membrane material;

[0034] Ⅲ Add 1 k...

Embodiment 2

[0039] A method for preparing a dialysis membrane for a hemodialyzer, comprising the steps of:

[0040] Ⅰ Dissolve 1kg of 3,4-dihydroxyfuran-2,5-dicarboxylate diethyl ester and 2kg of 4,6-bis(1-adamantyl)-1,3-diglycidyl ether benzene in N,N - Add 0.35 kg of potassium carbonate to 11 kg of dimethylformamide, stir and react for 12.5 hours in a helium atmosphere at 77 ° C, and then precipitate in water, then filter the precipitated polymer with suction, and then place it in a vacuum drying oven Dried to constant weight at 93°C to obtain an adamantylfuryl polycondensate;

[0041] Ⅱ Dissolve 1 kg of the adamantyl furyl polycondensate prepared in step I in 4.5 kg of N,N-dimethylformamide, and obtain a spinning solution after vacuum defoaming treatment, and pour the spinning solution into the spinning solution tank , adjust the pressure to 3.2 atmospheres, control the temperature to 73 degrees Celsius, and control the rotating speed of the collection drum to 820 rpm, and then spin to ...

Embodiment 3

[0047] A method for preparing a dialysis membrane for a hemodialyzer, comprising the steps of:

[0048] Ⅰ Dissolve 1kg of 3,4-dihydroxyfuran-2,5-dicarboxylate diethyl ester and 2kg of 4,6-bis(1-adamantyl)-1,3-diglycidyl ether benzene in N-methyl Add 0.4 kg of sodium hydroxide to 13 kg of pyrrolidone, stir and react for 13 hours in a neon atmosphere at 79 ° C, then precipitate in water, then filter the precipitated polymer with suction, and then place it in a vacuum drying oven at 95 ° C Dry to constant weight to obtain adamantyl furyl polycondensate;

[0049] II Dissolving 1 kg of the adamantyl furyl polycondensate prepared in step I in 5 kg of N,N-dimethylformamide, vacuum defoaming treatment to obtain a spinning solution, injecting the spinning solution into a spinning solution tank, Adjust the pressure to 3.5 atmospheres, control the temperature to 75 degrees Celsius, and control the rotating speed of the collection drum to 850 rpm, and then spin to obtain the membrane mat...

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Abstract

The invention discloses a preparation method of a dialysis membrane for a hemodialyzer. The preparation method comprises the following steps: (I) preparing a diamond alkyl furanyl condensation polymer; (II) preparing a membrane material in a spinning manner; (III) preparing an intermediate product; (IV) preparing a surface modified membrane material; and (V) doping an anticoagulant. The inventionalso discloses a dialysis membrane for a hemodialyzer prepared according to the preparation method of the dialysis membrane for the hemodialyzer. The dialysis membrane for the hemodialyzer disclosed in the invention is good in biocompatibility, blood compatibility, hydrophilicity and smoothness, high in removal rate and hyperfiltration coefficient, and capable of effectively prolonging the life and dialysis age of a patient.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and relates to a blood purification device element, in particular to a dialysis membrane for a hemodialyzer and a preparation method thereof. Background technique [0002] In recent years, the number of kidney disease patients at home and abroad is increasing day by day, and the mortality rate is also increasing. In the case of insufficient kidney donor organs and low matching success rate, hemodialysis is still one of the main means of renal replacement therapy for patients with acute and chronic renal failure. It drains the blood from the body to the outside of the body through a dialyzer composed of countless hollow fibers. The blood and the electrolyte solution (dialysate) with a similar concentration to the body are exchanged through diffusion / convection inside and outside the hollow fibers. , remove metabolic waste in the body, maintain electrolyte and acid-base balance; remove exc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D61/14B01D67/00B01D69/08B01D71/76A61M1/16
CPCA61M1/16B01D61/145B01D67/0088B01D67/0093B01D69/087B01D71/76
Inventor 万迎春邓生卫李俊
Owner 湖南博隽生物医药有限公司
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