Mild composition for use in topical treatment of skin and nail disorders caused by virus and fungus
A topical composition and composition technology, applied in the direction of skin diseases, antifungal agents, antiviral agents, etc., to achieve the effect of improving permeability
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Embodiment 1
[0046] The formulation in Example 1 was prepared by mixing the ingredients specified in Table 1 below. The mixture was then heated on a water bath until a clear solution was obtained. After 2 hours and after 4 days, the appearance of the different formulations was directly inspected visually. Readouts are included in Table 1.
[0047] Table 1. The effect of different concentrations of oleth-20 and zinc sulfate on the clarity of the preparation.
[0048]
[0049] Table 1 (continued).
[0050]
[0051] *Given in the amount of Zn-salt added:
[0052] 5% by weight of zinc salt is equivalent to 1.1% by weight of Zn;
[0053] 3% by weight zinc salt equivalent to 0.7% by weight Zn; and
[0054] 7% by weight of zinc salt corresponds to 1.6% by weight of Zn.
[0055] From these experiments it was found that oleth-20 produced a clear solution over a very narrow and bell-shaped concentration range. Small changes in zinc concentration do not alter solubility.
Embodiment 2
[0057] To confirm the increased skin penetration putative by the combination of alpha hydroxy acids and methyl salicylate, an objective measurement protocol was used. use Combo (Cortex Technology, Hadsund, Denmark) was used for measurement. Skin color measurements are based on an active color detecting chip with white LEDs providing illumination and a measure of erythema equivalent to the redness of the skin (hemoglobin). The diameter of the measured target area was 7 mm. A surrogate marker, methyl nicotinate 0.4% in ethanol, was used because it caused skin redness as it penetrated the skin. Increased redness means that a large amount of methyl nicotinate has penetrated into the skin and thus absorption has increased. Since the uptake of the active complex of the invention to Zn ions, acid and methyl salicylate could not be measured in this way, methyl nicotinate was used as a surrogate marker. Therefore, the formulations in Table 2 are not formulations of the invention. ...
Embodiment 3
[0064] The formulation in Example 3 was prepared by mixing the ingredients given in the upper part of Table 3. The mixture was then heated on a water bath until a clear solution was obtained. The appearance of the different formulations was checked visually after 1 hour. Readouts are included in the lower part of Table 3. Formulations 3B, 3D and 3E are for comparison only. Only 3C is the invention.
[0065] Table 3. Effect of each ingredient on the degree of erythema.
[0066] 3B (comparison) 3C 3D (contrast) 3E (comparison) Element w％ w％ w％ w％ glycolic acid 0 65 65 65 Methyl salicylate 5 5 0 5 Oleth-20 10 10 0 10 ZnSO 4 wxya 2 O*
5 5 5 0 water 80 15 30 20 total 100 100 100 100 Appearance 1h Opalescence clarify clarify clarify Effect on skin blockage (40μL 6h) Visible readout 2min - + - ++ Erythema 2min 11 14.3 13 15 Visible readout for 48 h...
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