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Application of traditional Chinese medicine composition in preparation of anti-novel coronavirus drug

A coronavirus and composition technology, applied in the field of medicine, can solve the problems of acute onset of new coronary pneumonia, no antiviral drugs, and high mortality, and achieve the effects of stable disease, fast symptom relief time, and good safety.

Inactive Publication Date: 2021-02-05
GUANGZHOU WANGLAOJI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Compared with diseases caused by other viruses, COVID-19 has the characteristics of rapid onset, severe illness, and high fatality rate. Currently, there is no targeted antiviral drug

Method used

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  • Application of traditional Chinese medicine composition in preparation of anti-novel coronavirus drug
  • Application of traditional Chinese medicine composition in preparation of anti-novel coronavirus drug
  • Application of traditional Chinese medicine composition in preparation of anti-novel coronavirus drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1: a kind of preparation method of Chinese medicine extract

[0043] a. Take 72g honeysuckle, 72g skullcap, 72g nepeta, 72g gardenia, 72g forsythia, 72g scrophulariaceae, 43g silkworm, 108g rehmannia glutinosa, 22g shegan, 43g bellflower, 43g mint, 43g cicada slough, 43g windproof, 22g licorice for later use ;

[0044] b. The above fourteen flavors, honeysuckle, nepeta, windproof, and peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted twice with 65% ethanol under reflux, each time for 2 hours, and the extracts are combined, filtered, and medicinal The dregs are set aside, the filtrate recovers ethanol, add appropriate amount of water, boil, filter while it is hot, and the filtrate is set aside; take the dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting volatile oil, and the rest of the fried gardenia and other nine flavors, add water and decoct twice, t...

experiment example 1

[0046] Experimental example 1: Evaluation of the effect of drugs against the new coronavirus (SARS-COV-2) at the cellular level.

[0047] 1. Experimental materials:

[0048] 1. Test drug: Keganliyan extract, Keganliyan extract, provided by Guangzhou Wanglaoji Pharmaceutical Co., Ltd. (batch number: 191201), prepared according to the method of Example 1. See Table 1-1 and 1-2 for drug names and concentrations.

[0049] 2. Cells: VeroE6 cells, preserved by the virus room of the State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health.

[0050] 3. Virus: SARS-CoV-2, titer is TCID 50 =10 -6 / 100μL, stored at -80°C by BSL-3 Laboratory of Guangzhou Customs Technology Center (Highly Pathogenic Pathogenic Microorganism Research Laboratory of State Key Laboratory of Respiratory Diseases). Use a viral titer of 100TCID 50 .

[0051] 2. Experimental method:

[0052] 1. Antiviral experiment of tested drugs

[0053] 1.1 Test drug:

[0054] Table 1-1: ...

experiment example 2

[0077] Experimental Example 2: Clinical Observation of Keganliyan Oral Liquid on Relieving Throat Symptoms of New Coronary Pneumonia Recovery Period, Suspected Patients and Other Susceptible Groups

[0078] 1. Research Methods

[0079] 1. Subject selection criteria

[0080] 1.1 Diagnostic criteria

[0081] 1) Suspected cases

[0082] Comprehensive analysis combined with the following epidemiological history and clinical manifestations:

[0083]Epidemiological history: (1) within 14 days before the onset, there was a travel history or residence history in Wuhan and surrounding areas, or other communities with case reports; ) have a history of contact. (3) Have been in contact with patients with fever or respiratory symptoms from Wuhan City and surrounding areas, or from communities with case reports within 14 days before the onset of illness. (4) Aggregate disease.

[0084] Clinical manifestations: (1) fever and or respiratory symptoms; (2) with the imaging features of th...

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Abstract

The invention provides application of a traditional Chinese medicine composition in preparation of an anti-novel coronavirus drug. The traditional Chinese medicine composition is a Kegan sore-throat relieving composition, and in-vitro experimental results show that the anti-novel coronavirus effect means that the composition can inhibit Vero E6 cells infected with novel coronavirus from causing cytopathy and inhibit mRNA over-expression of inflammatory factors TNF-a, IL6, IL-8 and MCP-1 induced by SARS-CoV-2. Clinical test results show that the Kegan sore-throat relieving composition has a higher symptom relieving rate and shorter symptom relieving time for novel coronary pneumonia symptoms such as fever, cough and pharyngalgia and the like, and can stabilize the condition of a patient ina novel coronary pneumonia recovery period; and no adverse drug event occurs, and the safety is good.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of a traditional Chinese medicine composition in the preparation of anti-new coronavirus drugs. Background technique [0002] Keganliyan Oral Liquid, see Chinese Pharmacopoeia 2015 Edition, Part 928 (2020 Edition, Part 994), prescription: Honeysuckle 72g, Scutellaria baicalensis 72g, Nepeta 72g, Stir-fried Gardenia 72g, Forsythia 72g, Scrophulariaceae 72g, Silkworm 43g, Rehmannia glutinosa 108g, Shegan 22g, Campanulaceae 43g, Mint 43g, Cicada slough 43g, Fangfeng 43g, Licorice 22g. Its preparation method: extract the volatile oil from the above fourteen flavors, honeysuckle, nepeta, windproof, and peppermint, and collect the distilled aqueous solution in another device; add 65% ethanol to reflux to extract twice, each time for 2 hours, combine the extracts, and filter , the dregs are set aside, the filtrate recovers ethanol, add appropriate amount of water, boil, filter w...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P31/14A61P11/00A61K35/64
CPCA61K35/64A61K36/238A61K36/346A61K36/355A61K36/484A61K36/534A61K36/538A61K36/539A61K36/634A61K36/744A61K36/804A61K36/808A61K36/88A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P11/00A61P31/14A61K2300/00
Inventor 方广宏陈伟平郑荣波黄晓丹杨子峰伍柏坚胡冠英和海龙马钦海罗燕玉朱志红
Owner GUANGZHOU WANGLAOJI PHARM CO LTD
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