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Composition and method for reducing drug tolerance in patients with hormone dependent diseases

A technology of composition and androgen receptor, which is applied in the direction of drug combination, disease, allergic disease, etc., and can solve the problem of not being able to affect the degradation of 5β-abi

Active Publication Date: 2021-02-23
CENT FOR EXCELLENCE IN MOLECULAR CELL SCI CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, dutasteride can only inhibit the formation of 5α-Abi-related metabolites and cannot affect the degradation of 5β-abi

Method used

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  • Composition and method for reducing drug tolerance in patients with hormone dependent diseases
  • Composition and method for reducing drug tolerance in patients with hormone dependent diseases
  • Composition and method for reducing drug tolerance in patients with hormone dependent diseases

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Embodiment Construction

[0056] It should be understood that within the scope of the present invention, the above-mentioned technical features of the present invention and the technical features specifically described in the following (such as the embodiments) can be combined with each other to form a preferred technical solution.

[0057] Unless otherwise indicated, the following terms used herein have the following meanings:

[0058] "Hydrogen (H)" as used herein includes the D and T isotopes thereof.

[0059] "Patient" or "subject" are used synonymously and include humans and animals. "Mammal" refers to humans and other mammals. Other animals include pets and livestock and the like.

[0060] "Alkyl" refers to an aliphatic saturated hydrocarbon group, which may be straight or branched, with a carbon chain length of 1-12 carbon atoms, preferably 1-6 carbon atoms, more preferably 1-4 carbon atoms.

[0061] "Alkoxy" refers to an oxy group (-O-) substituted with an alkyl group as described herein. A...

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Abstract

The present invention relates to a composition and a method for reducing drug tolerance in patients with hormone dependent diseases. The composition contains a reagent capable of inhibiting an expression of 3beta HSD and / or an activity thereof, an androgen receptor antagonist and / or a CYP17A inhibitor.

Description

technical field [0001] The present invention relates to compositions and methods for reducing drug tolerance in patients with hormone-dependent disorders. Background technique [0002] Steroids play an important role in a variety of physiological and pathological processes. Glucocorticoids play an important role in inflammation and bone development. Androgen and estrogen are closely related to prostate cancer, breast cancer and other diseases. Among them, prostate cancer is the cancer with the first incidence rate and the second death rate among Western men, and it is the cancer with the fastest-growing incidence rate and death rate among Chinese men. Androgen binds to androgen receptor (AR), activates AR signaling pathway, and promotes the occurrence and development of prostate cancer. Early prostate cancer uses testosterone (T) secreted by the testis to convert it into dihydrotestosterone (DHT) to activate the AR signaling pathway and maintain tumor growth. Therefore, ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61P5/28A61P15/08A61P17/00A61P17/10A61P17/14A61P29/00A61P35/00A61P37/08A61K31/352A61K31/7105A61K39/395
CPCA61K45/06A61P5/28A61P35/00A61P17/00A61P17/10A61P17/14A61P15/08A61P37/08A61P29/00A61K39/39566A61K31/7105A61K31/352A61K2300/00
Inventor 李振斐唐静洁梅泽洁高媛媛吴登龙黄盛松
Owner CENT FOR EXCELLENCE IN MOLECULAR CELL SCI CHINESE ACAD OF SCI