Application of gene marker combination in lung cancer screening and prognosis judgment

A marker and molecular marker technology, applied in the field of disease diagnosis, can solve the problems of lung injury, risk, and low sensitivity of ultrasound diagnosis

Pending Publication Date: 2021-03-19
BEIJING MEDINTELL BIOMED CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The sensitivity of ultrasound diagnosis is low, and lung puncture will damage the lungs of patients, which is risky and difficult to promote. As a result, many patients are not diagnosed until the decompensa

Method used

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  • Application of gene marker combination in lung cancer screening and prognosis judgment
  • Application of gene marker combination in lung cancer screening and prognosis judgment
  • Application of gene marker combination in lung cancer screening and prognosis judgment

Examples

Experimental program
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Effect test

Embodiment 1

[0047] Example 1 Gene markers related to diagnosis and prognosis of lung cancer

[0048] 1. Data download

[0049] The RNA-seq data and clinical information of lung adenocarcinoma were downloaded from the TCGA database. After removing the samples with missing survival information, the remaining sample size was paracancerous:carcinoma=59:500. The microarray data and clinical information of the GSE31210 dataset were downloaded from GEO, and the sample size was paracancerous:cancerous=20:226.

[0050] 2. Data standardization

[0051] For TCGA RNA-seq data, the Voom method was used for normalization, and for GEO chip data, the RMA method was used for normalization.

[0052] 3. Differential expression analysis

[0053] The "limma" package in R software was used for differential expression analysis, and the screening criteria for differential genes was adj.Pvalue1. Under this standard, there were 3948 differentially expressed genes in TCGA, 1504 upregulated differentially expres...

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Abstract

The invention discloses application of a gene marker combination in lung cancer screening and prognosis judgment. The gene marker can effectively diagnose lung cancer and reduce the omission factor oflung cancer, is very beneficial to early diagnosis and early treatment of lung cancer, is greatly helpful for improving lung cancer prognosis and reducing the death rate of lung cancer, and has goodclinical application and popularization values.

Description

technical field [0001] The present invention relates to the field of disease diagnosis, more specifically, the present invention relates to the application of gene marker combination in lung cancer screening and prognosis judgment. Background technique [0002] Lung cancer is the malignant tumor with the highest incidence rate in China and the world, and it is also the leading cause of cancer death in men. The incidence of lung cancer in the female population is second only to breast cancer. Global Burden of Disease (GBD) data shows that in 2016, the number of people suffering from trachea, bronchus or lung cancer in the world exceeded 2.8 million, of which the number of patients in China was as high as 1 million. In 2016, the number of deaths from the above-mentioned cancers worldwide was 1.7 million, accounting for 3.12% of the total deaths. In 2016, the number of patients who died in China was 590,000, accounting for 6.11% of the total number of deaths. Statistics show...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/11G16B25/10G16B25/20G16B40/10G16H50/30
CPCC12Q1/6886G16B40/10G16B25/10G16B25/20G16H50/30C12Q2600/118C12Q2600/158
Inventor 杨承刚宋宏涛
Owner BEIJING MEDINTELL BIOMED CO LTD
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