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Method for preparing pigment-containing sorbitol tabletting matrix

A technology of sorbitol and pigment, which is applied in the field of preparation of sorbitol tablet matrix containing pigment, can solve problems such as easy caking coloring, high pigment addition amount, unevenness, etc., achieve uniform coloring, solve white spots, and not easy Hygroscopic and caking effects

Inactive Publication Date: 2021-03-26
ZHEJIANG HUAKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a method for preparing a pigment-containing sorbitol tablet matrix, by coating sorbitol with a pigment in a fluidized bed coating machine, to solve the problem of pigment in the sorbitol tablet matrix. The addition amount is high, the problem of easy agglomeration and uneven coloring in the preparation process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The first embodiment of the method for preparing the pigmented sorbitol tablet matrix of the present invention comprises the following steps:

[0028] Step 11. Weigh 250 kg of sorbitol and 75 g of bright blue pigment with a particle size of 40 mesh to 200 mesh respectively, and the weight of bright blue pigment accounts for 0.03%.

[0029] Step 12, add 75g of bright blue pigment and 30kg of water to prepare a pigment coating solution, the mass fraction of pigment is 0.25%.

[0030] Step 13, the sorbitol raw material is transferred to the fluidized bed coater, the pigment coating solution is input into the coater by a peristaltic pump, and the sorbitol raw material granules are coated by the fluidized bed coater. During the coating process, the temperature of the coating machine is controlled at 45°C~55°C, the compressed air pressure is 0.3Mpa~0.6Mpa, the coating liquid feed speed is 60rpm~80rpm, the coating process time is 100min, and the obtained Blue uniform sorbitol...

Embodiment 2

[0034] The second embodiment of the method for preparing the pigment-containing sorbitol tablet matrix includes the following steps:

[0035] Step 21. Weigh 250 kg of sorbitol and 50 g of sunset yellow pigment with a particle size of 40 mesh to 200 mesh respectively, and the weight of sunset yellow pigment accounts for 0.02%.

[0036] Step 22, add 50g of sunset yellow pigment and 35kg of water to prepare a pigment coating solution, the mass fraction of the pigment is 0.14%.

[0037] Step 23, the sorbitol raw material is transferred to the fluidized bed coater, the pigment coating solution is input into the coater by a peristaltic pump, and the sorbitol raw material particles are coated by the fluidized bed coater. During the coating process, the temperature of the coating machine is controlled at 45°C~55°C, the compressed air pressure is 0.3Mpa~0.6Mpa, the coating liquid feed speed is 60rpm~80rpm, the coating process time is 140min, and the obtained Yellow uniform sorbitol ta...

Embodiment 3

[0041] The third embodiment of the method for preparing the pigment-containing sorbitol tablet matrix includes the following steps:

[0042] Step 31. Weigh 250 kg of sorbitol and 100 g of indigo pigment with a particle size of 40 mesh to 200 mesh respectively, and the weight of indigo pigment accounts for 0.04%.

[0043] Step 32, adding 100 g of indigo pigment to 33.3 kg of water to prepare a pigment coating solution, the mass fraction of the pigment is 0.3%.

[0044] Step 33, the sorbitol raw material is transferred to the fluidized bed coater, the pigment coating solution is input into the coater by a peristaltic pump, and the sorbitol raw material particles are coated by the fluidized bed coater. During the coating process, the temperature of the coating machine is controlled at 45°C~55°C, the compressed air pressure is 0.3Mpa~0.6Mpa, the coating liquid feed speed is 65rpm~90rpm, the coating process time is 150min, and the obtained Blue uniform sorbitol tablet base granule...

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Abstract

The invention relates to a method for preparing a pigment-containing sorbitol tabletting matrix. The method is characterized in that sorbitol particles are coated with a pigment coating solution in afluidized bed coating machine to obtain pigment-containing sorbitol tabletting matrix particles. The method comprises the following steps: 1, a sorbitol raw material with the particle size of 40 meshes and 200 meshes and a pigment are prepared respectively, and the weight of the pigment is 0.02%-0.04% of that of sorbitol; 2, a pigment coating solution is prepared: adding water to the pigment, andperforming stirring uniformly to prepare the pigment coating solution with the mass fraction of 0.03%-0.3%; and 3, the sorbitol raw material is transferred into a fluidized bed coating machine, the pigment coating solution is input into the coating machine through a peristaltic pump, and coating treatment is performed on sorbitol raw material particles. By adopting the method for coating sorbitolwith the pigment in the fluidized bed coating machine, the problems that the addition amount of the pigment in the sorbitol tabletting matrix is high, agglomeration occurs easily in the preparation process and coloring is uneven are solved.

Description

technical field [0001] The invention belongs to the technical field of sugar alcohol preparation, in particular to a method for preparing a pigment-containing sorbitol tablet matrix. Background technique [0002] Tablet candy is a solid candy made of sweeteners as the main raw materials, adding auxiliary materials, mixing and tableting. As a sweetener, sorbitol is increasingly used in tableted confectionery because of its good compressibility. In compressed confectionary products, various coloring agents are often added to give the product an appearance. [0003] At present, the commonly used method of combining pigments and sweeteners such as sorbitol is mainly to directly mix and compress tablets. The main problem therein is that pigments need a relatively large amount of addition to achieve a better coloring effect. The patent of publication number CN110693842A provides a method of adding bright blue pigment into the binder solution and spraying it into the raw material...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L27/30A23L5/42A23P20/15
CPCA23L27/34A23L5/42A23P20/15
Inventor 汪秀秀罗家星魏子尧毛宝兴吴爱娟林翠曾方明
Owner ZHEJIANG HUAKANG PHARMA
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