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Lead compound of tumor treatment electric field, preparation method of lead compound and sensitization tumor treatment electric field

A leading compound and tumor treatment technology, applied in the field of tumor treatment electric field, can solve problems such as adverse reactions, achieve the effects of reducing adverse reactions, improving safety and effectiveness, and enhancing biological responses

Pending Publication Date: 2021-03-30
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The invention provides a lead compound of a tumor treatment electric field, a preparation method thereof, and a sensitized tumor treatment electric field, so as to solve the technical problem that the application of the existing tumor treatment electric field has adverse reactions

Method used

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  • Lead compound of tumor treatment electric field, preparation method of lead compound and sensitization tumor treatment electric field
  • Lead compound of tumor treatment electric field, preparation method of lead compound and sensitization tumor treatment electric field
  • Lead compound of tumor treatment electric field, preparation method of lead compound and sensitization tumor treatment electric field

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preparation example Construction

[0036]According to another aspect of the present invention, there is also provided a preparation method of a pilot compound of the above tumor therapy electric field, including the following steps:

[0037]Stripchaoxicab, the oxide oxide oxide was added to a phosphate buffer having a percentage of 10% to 50%, and shakes even under 4 ° C ~ 40 ° C, and the reaction 2H ~ 24H is obtained from the yolstone modified Xi Soft. The mixture of the thyoxicon, the mixture is 50,000 rpm to 25,000 rpm, centrifugation 2H ~ 2.5H, removes the supernatant, and the water resuspended, obtaining the oxide oxide-modified Sbuxi monohydration ;

[0038]Add a three-iron dioxide to the oxide-modified tetuximoxiciform anti-suspension, and shake even under 4 ° C ~ 40 ° C, the reaction is 8h ~ 12h, and then at 20,000 rpm to 25000 rpm, centrifuge To remove the supernatant, the supernatant is removed from 2 h to 2.5 h.

[0039]The above-mentioned oxidized graphene and the three-iron dioxide were used in nanometers, and th...

Embodiment 1

[0054]The oxide oxide is purified by dialysis, and is formulated as a concentration of 1 mg / ml. Under the conditions of the US MISONIX ultrasonic crusher Sonicator 3000 strength 3.5, it continuously for 2 hours, the mode works for 10 seconds, and the rest is 5 seconds. Note that the whole process is carried out in the ice water mixture. After the ultrasound end, filter with 0.22 μm filter, produce the graphene, NanoDrop measurement final concentration, refrigerating ready;

[0055]1 mg of Sbuxi monoclum, 0.2 mg of oxide oxide was added 1 mL of volume percent of 10% phosphate buffer, shaken even at 4 ° C, reaction for 12 hours, to obtain Xucitcuximabs modified by oxide oxide The mixture was mixed with a mixture of 200,000 rpm, centrifuged for 2 h. After removing the supernatant, 1 ml of deionized water was horeed, and the oxidized graphene modified Sbuxi monocloxa;

[0056]The 1 mg of tetraned oxide was added to the oxide-modified tetuximoxiciform anti-suspension, and the particle diamet...

Embodiment 2

[0058]The difference in Example 1 is that 1 mg of Sbuxi monoclonal, 0.2 mg of oxide, and 0.6 mg of tetraned iron.

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Abstract

The invention discloses a lead compound of a tumor treatment electric field, a preparation method of the lead compound and a sensitization tumor treatment electric field, the lead compound comprises atumor antibody, graphene oxide and ferroferric oxide, and the tumor antibody, the graphene oxide and the ferroferric oxide are connected through non-covalent bonds; and the tumor antibody is a cetuximab. According to the lead compound of the tumor treatment electric field, the tumor antibody, graphene oxide and ferroferric oxide are connected through non-covalent bonds to form the lead compound of the tumor treatment electric field. The glioma cell mitosis is effectively blocked in a medium-frequency low-intensity electric field, glioma cell proliferation is inhibited, glioma cell death is promoted, and glioma cells are killed. The formed lead compound effectively and directly kills most of tumor cells, and can greatly enhance the biological reaction. Moreover, the lead compound of the tumor treatment electric field can sensitize the electric field, reduce the adverse reaction of scalp and improve the safety and effectiveness of killing glioma cells.

Description

Technical field[0001]The present invention relates to the field of tumor therapy, in particular, to a pilot compound of a tumor therapy electric field. Further, the present invention relates to a preparation method including a pilot compound including the above tumor therapy electric field, a sensitization tumor treatment electric field.Background technique[0002]The tumor treatment electric field is a new new tumor treatment means in recent years. At present, there are many internal and external experiments that have been confirmed that the tumor treatment electric field has a strong clinical therapeutic effect on tumors, and is approved by the Food and Drug Administration (FDA), FOOD AND DRUG Administration, FDA. However, the application of tumor treatment electric fields, the most common adverse reactions are adverse reactions of the electrode sheet contact portion, and is usually used for patients with surgery and scars for scarns, resulting in scalp infection, and the next need ...

Claims

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Application Information

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IPC IPC(8): A61K47/52A61K39/395A61P35/00A61K50/00
CPCA61K47/52A61K39/39558A61P35/00A61K9/0009
Inventor 刘志雄许胜超罗承科陈凌肖志强
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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