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Medicine for treating consciousness disorder and preparation method of medicine

A consciousness disorder and drug technology, applied in the direction of medical formula, drug combination, separation method, etc., can solve the problems of drug stability decrease, pH value and temperature control not in place, drug effect is not obvious, etc., to improve curative effect, accelerate Filter, filter better effect

Inactive Publication Date: 2021-04-09
哈尔滨医大药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to make up for the deficiencies of the prior art and solve the problem that the existing preparation method does not control the pH value and temperature in place, which leads to the decrease of the stability of the drug and the inconspicuous effect of the drug, the present invention proposes a treatment for disturbance of consciousness medicine and its preparation method

Method used

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  • Medicine for treating consciousness disorder and preparation method of medicine
  • Medicine for treating consciousness disorder and preparation method of medicine
  • Medicine for treating consciousness disorder and preparation method of medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] S1: Add water for injection into container A, and add the prescribed amount of citicoline sodium, keep the temperature at 5°C, then add water for injection to make a concentrated solution of citicoline sodium, then use 0.1mol / L hydrochloric acid or Adjust the pH value with sodium hydroxide solution, then add activated carbon, keep the temperature for 10 minutes, and then use a filter device to filter and decarbonize;

[0030] S2: Add water for injection into container B, and heat it to 5°C, then add the prescribed amount of mannitol, stir while heating until completely dissolved, then add water for injection, the temperature is 5°C, and the total volume of mannitol solution Add activated carbon at 0.3‰ (w / v), keep the temperature for 10 minutes, and then use a filter device to filter and decarbonize;

[0031]S3: After combining the concentrated solution filtered and decarburized in S1 with the mannitol solution in S2, add water for injection, open the valve of the water...

Embodiment 2

[0033] S1: Add water for injection into container A, and add the prescribed amount of citicoline sodium, keep the temperature at 8°C, then add water for injection to make a concentrated solution of citicoline sodium, then use 0.2mol / L hydrochloric acid or Adjust the pH value with sodium hydroxide solution, then add activated carbon, keep the temperature for 5 minutes, and use a filter device to filter and decarbonize;

[0034] S2: Add water for injection to container B, and heat it to 8°C, then add the prescribed amount of mannitol, stir while heating until it is completely dissolved, then add water for injection, the temperature is 8°C, according to the total volume of mannitol solution Add activated carbon at 0.8‰ (w / v), keep the temperature for 5 minutes, and use a filter device to filter and decarbonize;

[0035] S3: After combining the concentrated solution filtered and decarburized in S1 with the mannitol solution in S2, add water for injection, open the valve of the wat...

Embodiment 3

[0037] S1: Add water for injection into container A, and add the prescribed amount of citicoline sodium, keep the temperature at 10°C, then add water for injection to make a concentrated solution of citicoline sodium, then use 0.5mol / L hydrochloric acid or Adjust the pH value with sodium hydroxide solution, then add activated carbon, keep the temperature for 10 minutes, and then use a filter device to filter and decarbonize;

[0038] S2: Add water for injection into container B, and heat it to 10°C, then add the prescribed amount of mannitol, stir while heating until it is completely dissolved, then add water for injection, the temperature is 10°C, according to the total volume of mannitol solution Add activated carbon at 1.5‰ (w / v), keep the temperature for 10 minutes, and use a filter device to filter and decarbonize;

[0039] S3: After combining the concentrated solution filtered and decarburized in S1 with the mannitol solution in S2, add water for injection, open the valv...

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Abstract

The invention belongs to the technical field of medicine preparation, and particularly relates to a medicine for treating consciousness disorder and a preparation method of the medicine. The preparation method is as follows: S1, adding water for injection into a container A, adding citicoline sodium according to a prescription amount, keeping the temperature at 5-100 DEG C, then adding the water for injection to prepare a citicoline sodium concentrated solution, adjusting the pH value with 0.1-3mol / L hydrochloric acid or sodium hydroxide solution, then adding activated carbon, keeping the temperature for 5-55 minutes, and then performing filtering and decarburizing by using a filtering device; And S2, adding the water for injection into a container B, performing heating to 5-100 DEG C, then adding mannitol according to a prescription dosage, performing stirring while heating until the mannitol completely dissolves, then adding the water for injection at the temperature of 5-100 DEG C, adding activated carbon accounting for 0.03-0.3% (w / v) of the total volume of the mannitol solution, keeping the temperature for 5-55 minutes, and then performing filtering and decarburizing by using a filtering device. The influence of the pH value and the temperature on the stability and the effect of the medicine is reduced, and the curative effect of treating acute craniocerebral trauma and brain postoperative consciousness disturbance can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, in particular to a medicine for treating disturbance of consciousness and a preparation method thereof. Background technique [0002] Consciousness refers to the individual's confirmation of the external environment, his own situation and their interrelationships. Consciousness activities include both awakening and conscious content. When the ascending reticular activation system and the extensive damage to the cerebral cortex can lead to obstacles in different degrees of awakening, and consciousness Changes in content are mainly caused by cerebral cortical lesions, and disturbance of consciousness seriously affects people's lives. Therefore, drugs are often used to treat disturbance of consciousness in clinical practice. [0003] In the prior art, there have also been some technical solutions for drugs for disturbance of consciousness. For example, a Chinese patent whose application...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7068A61K9/08A61K47/26A61P25/00A61P25/28B01D36/00
CPCA61K9/08A61K31/7068A61K47/26A61P25/00A61P25/28B01D36/00
Inventor 王立艳刘培伟周萍高曈张宇宏李佳琳
Owner 哈尔滨医大药业股份有限公司
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