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Application of oroxylin in preparation of medicine for treating psoriasis

A technology of psoriasis and psoriasis, which is applied in the field of medicine, can solve the problems of lack of psoriasis, and achieve the effects of improving pathological scores, low toxicity and side effects, and alleviating the formation of scales

Inactive Publication Date: 2021-04-16
南京芩领医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report that kelpifene is used to prepare psoriasis treatment drugs

Method used

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  • Application of oroxylin in preparation of medicine for treating psoriasis
  • Application of oroxylin in preparation of medicine for treating psoriasis
  • Application of oroxylin in preparation of medicine for treating psoriasis

Examples

Experimental program
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Effect test

Embodiment 1

[0021] (1) Imiquimod (IMQ)-induced mouse model of psoriasis

[0022] Mice (C57BL / 6 mice, 18-22g, 6-8 weeks) were anesthetized with 0.1mL / 10g 3.5% chloral hydrate, the hair on the back of the mouse was shaved, and the skin of about 2cm×3cm was exposed on the back of the mouse. IMQ ointment (62.5 mg) was continuously applied to the back skin of mice for 6 days to induce psoriasis, and the control group was given the same dose of Vaseline ointment (Sham).

[0023] During the modeling period, the positive drug cyclosporine A (CSA, 30 mg / kg / day) or various doses of OA (20, 40, 80 mg / kg / day) were administered intragastrically. During the modeling process, the physiological indicators (body weight, skin changes) of the mice were monitored every day. The PASI scoring standard was used for clinical symptoms, and the indicators of erythema and scale 2 were evaluated, and the scores were scored from 0 to 4, and the total score was obtained by adding the scores of the three scores. PASI...

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Abstract

The invention discloses novel medical application of oroxylin, belonging to the technical field of medicines. The oroxylin is used for preparing the medicine for treating psoriasis; and due to low toxic and side effects, the oroxylin can be used as an anti-psoriasis medicine for subsequent development.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of psoriasis in the preparation of medicine for treating psoriasis. Background technique [0002] Psoriasis is a common chronic inflammatory disease involving a variety of cells, with a high recurrence rate and no complete cure. The pathological manifestations are mainly epidermal hyperkeratosis and parakeratosis, acanthocyte hypertrophy, immune cell infiltration, elevated levels of inflammatory factors, and vasodilation. At present, the prevalence rate in the world is about 1%-2%. Because its pathogenesis has not been fully elucidated, clinical treatment is relatively difficult, and only symptomatic treatment can be used to improve symptoms and improve the quality of life of patients. [0003] Psoriasis can be divided into mild, moderate, and severe according to the severity of the disease. Mild psoriasis generally uses topical drugs, including cort...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P17/06
Inventor 强磊何远郭青龙高源郭永健钟尤
Owner 南京芩领医药科技有限公司