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A Sivir tablet and tablet technology, applied in the field of remdesivir tablet and its preparation, can solve the problems of poor patient compliance and inconvenient administration forms
Inactive Publication Date: 2021-04-20
顾世海
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The drug needs to be injected under the guidance of professionals, the fo
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Embodiment 1
[0033] Raw materials: see Table 1. Among them, the pH regulator is acrylic Carbopol71G.
[0034] Preparation:
[0035] Step a, pass remdesivir, disintegrant, binder, lubricant, pH regulator and filler through a 100-mesh sieve, and set aside;
[0036] Step b, weigh the required amount of active drug remdesivir, 1 / 2 weight of disintegrant, 1 / 2 weight of binder, 1 / 2 weight of lubricant and 2 / 3 weight of filler Sieve, check the weight, mix by hand in an equal increment method, then put it into a mixer and mix at a speed of 30 rpm for two hours;
[0037] Step c, taking out the powder in the mixer, checking the total weight after weighing, placing the obtained powder in a dry granulator for granulation, passing through a 20-mesh sieve after granulation, and then passing through a 60-mesh sieve to obtain granules;
[0038] Step d, put the granules produced in step c and the remaining disintegrant, 1 / 2 weight binder, 1 / 2 weight lubricant, pH regulator and 1 / 3 weight filler into the...
Embodiment 2
[0046] Raw materials of tablet core: see Table 1. Wherein the pH regulator is Eudragit L100-55.
[0047] The preparation method of tablet core: with embodiment 1.
[0048] The film coating method of tablet core: with embodiment 1.
Embodiment 3
[0050] Raw materials of tablet core: see Table 1. Wherein the pH regulator is fumaric acid.
[0051] The preparation method of tablet core: with embodiment 1.
[0052] The film coating method of tablet core: with embodiment 1.
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Abstract
The invention discloses a Remdesivir tablet and a preparation method thereof. The tablet comprises a tablet core and a thin-film coating layer, wherein the tablet core comprises the following ingredients in parts by weight: 50-65% of Remdesivir, 4-7% of disintegrating agent, 4-7% of binding agent, 0.7-1.2% of lubricating agent, 0.1-0.9% of pH conditioning agent and the balance of filling agent, wherein the thin-film coating layer comprises the following ingredients: a coating material of a gastric-dissolved thin-film coating layer or the coating material of an enteric-coated thin-film coating layer, and the pH regulator is an organic acid type, a high-polymerization type or an alkalizer. The prepared Remdesivir tablet has good long-term stability and high blood concentration.
Description
technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a remdesivir tablet and a preparation method thereof. Background technique [0002] Remdesivir (Remdesivir) is a drug under research by Gilead Sciences. Remdesivir is a nucleoside analog with antiviral activity, with an EC50 value of 74nM against SARS-CoV and MERS-CoV in HAE cells and an EC50 value of 30nM against murine hepatitis virus in delayed brain tumor cells. [0003] A paper published online by the authoritative medical journal "New England Journal of Medicine" (NEJM) introduced a drug called remdesivir (Remdesivir) that showed good efficacy in fighting the new coronavirus, but its effectiveness Large-scale clinical trials are still needed to be further verified. Remdesivir (Remdesivir) has not been approved for marketing in any country, and its safety and effectiveness have not been confirmed. [0004] The research published in "Cell Research" shows that on ...
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Application Information
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