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Remdesivir tablet and preparation method thereof

A Sivir tablet and tablet technology, applied in the field of remdesivir tablet and its preparation, can solve the problems of poor patient compliance and inconvenient administration forms

Inactive Publication Date: 2021-04-20
顾世海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug needs to be injected under the guidance of professionals, the form of administration is inconvenient, and the patient's compliance is poor

Method used

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  • Remdesivir tablet and preparation method thereof
  • Remdesivir tablet and preparation method thereof
  • Remdesivir tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Raw materials: see Table 1. Among them, the pH regulator is acrylic Carbopol71G.

[0034] Preparation:

[0035] Step a, pass remdesivir, disintegrant, binder, lubricant, pH regulator and filler through a 100-mesh sieve, and set aside;

[0036] Step b, weigh the required amount of active drug remdesivir, 1 / 2 weight of disintegrant, 1 / 2 weight of binder, 1 / 2 weight of lubricant and 2 / 3 weight of filler Sieve, check the weight, mix by hand in an equal increment method, then put it into a mixer and mix at a speed of 30 rpm for two hours;

[0037] Step c, taking out the powder in the mixer, checking the total weight after weighing, placing the obtained powder in a dry granulator for granulation, passing through a 20-mesh sieve after granulation, and then passing through a 60-mesh sieve to obtain granules;

[0038] Step d, put the granules produced in step c and the remaining disintegrant, 1 / 2 weight binder, 1 / 2 weight lubricant, pH regulator and 1 / 3 weight filler into the...

Embodiment 2

[0046] Raw materials of tablet core: see Table 1. Wherein the pH regulator is Eudragit L100-55.

[0047] The preparation method of tablet core: with embodiment 1.

[0048] The film coating method of tablet core: with embodiment 1.

Embodiment 3

[0050] Raw materials of tablet core: see Table 1. Wherein the pH regulator is fumaric acid.

[0051] The preparation method of tablet core: with embodiment 1.

[0052] The film coating method of tablet core: with embodiment 1.

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Abstract

The invention discloses a Remdesivir tablet and a preparation method thereof. The tablet comprises a tablet core and a thin-film coating layer, wherein the tablet core comprises the following ingredients in parts by weight: 50-65% of Remdesivir, 4-7% of disintegrating agent, 4-7% of binding agent, 0.7-1.2% of lubricating agent, 0.1-0.9% of pH conditioning agent and the balance of filling agent, wherein the thin-film coating layer comprises the following ingredients: a coating material of a gastric-dissolved thin-film coating layer or the coating material of an enteric-coated thin-film coating layer, and the pH regulator is an organic acid type, a high-polymerization type or an alkalizer. The prepared Remdesivir tablet has good long-term stability and high blood concentration.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a remdesivir tablet and a preparation method thereof. Background technique [0002] Remdesivir (Remdesivir) is a drug under research by Gilead Sciences. Remdesivir is a nucleoside analog with antiviral activity, with an EC50 value of 74nM against SARS-CoV and MERS-CoV in HAE cells and an EC50 value of 30nM against murine hepatitis virus in delayed brain tumor cells. [0003] A paper published online by the authoritative medical journal "New England Journal of Medicine" (NEJM) introduced a drug called remdesivir (Remdesivir) that showed good efficacy in fighting the new coronavirus, but its effectiveness Large-scale clinical trials are still needed to be further verified. Remdesivir (Remdesivir) has not been approved for marketing in any country, and its safety and effectiveness have not been confirmed. [0004] The research published in "Cell Research" shows that on ...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K47/38A61K47/32A61K31/675A61P31/14A61P11/00
CPCA61K9/20A61K9/28A61K31/675A61K31/683A61K31/685A61K47/32A61K47/38A61P11/00A61P31/12A61P31/14
Inventor 顾世海丁延辉余艳贞张洪斌胡雪芹
Owner 顾世海
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