Method for continuously preparing 3, 5-dinitrobenzoic acid by using micro-channel reactor

A technology of dinitrobenzoic acid and microchannel reactor, which is applied in chemical instruments and methods, preparation of nitro compounds, chemical/physics/physicochemical processes, etc. "Warm" risk, long reaction time, etc.
CN112679358AActive Publication Date: 2021-04-20CHANGZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHANGZHOU UNIV
Publication Date
2021-04-20

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Abstract

The invention discloses a method for continuously preparing 3, 5-dinitrobenzoic acid by using a micro-channel reactor, and belongs to the technical field of organic synthesis processes. According to the method, benzoic acid and concentrated nitric acid are used as raw materials, fuming sulfuric acid is used as a solvent, trifluorosulfonic acid ketone is used as a catalyst, and the preparation process of 3, 5-dinitrobenzoic acid is continuously completed in a micro-channel reactor system. After the raw materials are introduced into the micro-channel reactor through a metering pump, the 3, 5-dinitrobenzoic acid product is obtained through preheating, mixed reaction and separation, the method can strictly control the temperature and the retention time in the reaction process, accurately control the reaction temperature to prevent temperature runaway, and improve the safety of a reaction device; and due to the strong mass transfer effect of the micro-channel reactor, the mass transfer effect among the raw materials in the reaction system is enhanced, and the reaction efficiency and the yield of 3, 5-dinitrobenzoic acid are greatly improved.
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Description

technical field

[0001] The invention belongs to the technical field of organic synthesis technology, and specifically relates to a method for preparing 3,5-dinitrobenzoic acid through nitration reaction using benzoic acid as a raw material and copper trifluorosulfonate as a catalyst, more specifically in a microchannel A method for continuously preparing 3,5-dinitrobenzoic acid through nitration reaction using benzoic acid as a raw material in a reactor. Background technique

[0002] 3,5-Dinitrobenzoic acid is an important fine chemical, pharmaceutical, and dye intermediate, mainly used in the preparation of diatrizoic acid, a diagnostic drug, which is a positive contrast agent for X-ray diagnosis, and is used for the preparation of diatrizoate meglumine, Sodium diatrizoate or compound diatrizoate meglumine injection is mainly used for urography, but also for angiography of cardiovascular, cerebrovascular, peripheral blood vessels, bile duct and various injection methods suc...

Claims

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