Eyeball-motion-positioning-based proton-heavy ion beam current gate control method for eyeball tumor radiotherapy

Abstract

The invention discloses an eyeball-motion-positioning-based proton-heavy ion beam current gate control method for eyeball tumor radiotherapy. The method comprises the steps: acquiring real-time images of an eyeball by utilizing eyeball motion image acquisition equipment, carrying out pixel graduation by utilizing a diameter of an iris, carrying out analysis so as to obtain a real-time motion displacement curve of the eyeball, setting a position deviation threshold, outputting a gate control signal to a proton-heavy ion treatment system through a communication unit, and then, controlling interruption and recovery of a proton-heavy ion beam current. According to the method, gate control on eyeball motion during proton-heavy ion radiotherapy of a malignant tumor of the eyeball is achieved, and the beam current of a proton-heavy ion device is interrupted when a deviation between an eyeball position and a reference position reaches a certain threshold; and the beam current is recovered when the deviation between the eyeball position and the reference position is smaller than the threshold, so that accurate radiotherapy of intraocular tumors is achieved, and the therapy efficiency is increased.

Description

technical field [0001] The invention relates to the field of radiation medicine, in particular to a proton heavy ion beam gating method based on eyeball movement positioning in eyeball tumor radiotherapy. Background technique [0002] Uveal malignant melanoma is a rare ocular malignancy, including choroidal melanoma, ciliary body melanoma, and iris melanoma. The incidence rate in Europe is 5-7 cases / year per million people, and the incidence rate in Asia is 0.4-0.6 cases / year per million people. The main treatment methods include enucleation, local excision, thermotherapy, photon radiotherapy, particle brachytherapy, and ion radiotherapy. Radiation therapy has become the main treatment for ocular malignant tumors. It has been reported in the literature that proton and heavy ion radiotherapy can provide better results in terms of tumor control, eye protection, vision and the incidence of adverse events. [0003] During ion radiation therapy for malignant tumors of the eyeb...

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Problems solved by technology

This patent also proposes a control method for multi-leaf grating automatic tracking during adaptive radiation therapy. However, the above-mentioned eye movement gating technology has deficiencies and needs to cooperate with electrooculogram (EOG) signals to obtain the real-time position of eye tumors. Signal diagram, in the actual clinical ion beam therapy process, if the EOG metal electrode patch is placed on the beam inflow path, it may affect the range of the proton heavy ion beam or affect the placement of the eyelid opener, affecting the accuracy of proton heavy ion radiation therapy

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