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Adjuvant immunotherapy medicine for tumors and application thereof

A technology of adjuvant therapy and drugs, applied in the field of biomedicine, can solve the problems of low survival rate of malignant tumors, adverse reactions, etc., and achieve the effect of enhancing the effect of tumor suppression, reducing toxic and side effects, and enhancing the inhibitory effect of chemical drugs

Pending Publication Date: 2021-05-04
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surgical treatment, chemotherapy and radiation therapy are commonly used methods in the comprehensive treatment of malignant tumors, but the survival rate of most malignant tumors is very low, and it also brings more adverse reactions while suppressing the tumor

Method used

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  • Adjuvant immunotherapy medicine for tumors and application thereof
  • Adjuvant immunotherapy medicine for tumors and application thereof
  • Adjuvant immunotherapy medicine for tumors and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Cut the whole Echinacea herb into 2-3cm long pieces, weigh 200g, add 8 times the weight of Echinacea in purified water, soak for 40min, heat and boil for 2h, filter out the concoction and suction filter. Add pure water 6 times the weight of Echinacea purpurea to the medicinal dregs, decoct for 1 hour, filter out the medicinal juice and suction filter, combine the two decoction liquids, filter, take the supernatant, concentrate the supernatant under reduced pressure to form an extract, freeze Dried into powder, added appropriate amount of auxiliary materials, made into tablets.

Embodiment 2

[0042] Cut the whole Echinacea herb into 2-3cm long pieces, weigh 200g, add 9 times the weight of Echinacea in purified water, soak for 30min, heat and boil for 3h, filter out the medicinal juice and suction filter. Add pure water 7 times the weight of Echinacea purpurea to the medicinal dregs, decoct for 1 hour, filter out the medicinal juice and suction filter, combine the two decoction liquids, filter, take the supernatant, concentrate the supernatant under reduced pressure to form an extract, freeze Dried, crushed into fine powder, packed in capsules.

Embodiment 3

[0044] Cut the whole Echinacea herb into 2-3cm long pieces, weigh 200g, add 10 times the weight of Echinacea in purified water, soak for 30min, heat and boil for 2h, filter out the medicinal juice and suction filter. Add pure water 8 times the weight of Echinacea purpurea to the medicinal dregs, decoct for 2 hours, filter out the medicinal juice and suction filter, combine the two decoction liquids, filter, take the supernatant, concentrate the supernatant under reduced pressure to form an extract, freeze Dried into powder, added appropriate amount of auxiliary materials, made into tablets.

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Abstract

The invention discloses an adjuvant immunotherapy medicine for tumors and an application thereof, and belongs to the field of bio-medicines. According to the present invention, an echinacea purpurea extract is used as the adjuvant immunotherapy medicine for tumors, so as to inhibit growth of tumors, enhance the inhibition effect of chemotherapeutics and relieve toxic and side effects in the chemoradiotherapy process. The adjuvant immunotherapy medicine has remarkable effect-enhancing and toxicity-reducing effects. A tumor-bearing mouse model is established to evaluate the inhibition effect of the adjuvant immunotherapy medicine on tumors in a tumor-bearing mouse. Results show that the echinacea purpurea can inhibit growth of tumors, improve body immunity, enhance the tumor inhibition effect of chemotherapeutics, reduce the toxic and side effects of chemotherapeutics on the liver, generate good toxicity-reducing and effect-enhancing effects, and has superior application prospects.

Description

technical field [0001] The invention belongs to the field of biomedicine, in particular to a drug for adjuvant tumor immune therapy and its application. Background technique [0002] In recent years, the morbidity and mortality of malignant tumors have shown a rapid upward trend, seriously threatening human health. Surgical treatment, chemotherapy and radiotherapy are commonly used methods in the comprehensive treatment of malignant tumors, but the survival rate of most malignant tumors is very low, and they also bring more adverse reactions while suppressing tumors. It can cause a considerable degree of damage to normal cells in the human body, causing various inflammatory reactions such as liver and kidney toxicity, digestive disorders, immune function decline, bone marrow suppression, and fever. Therefore, it is urgent to find drugs that can control the growth of malignant tumors and reduce adverse reactions. [0003] Traditional Chinese medicine plays an important role...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K45/06A61K31/513A61K33/243A61K31/337A61K31/704A61K31/675A61K31/407A61P37/04A61P35/00
CPCA61K31/337A61K31/407A61K31/513A61K31/675A61K31/704A61K36/28A61K45/06A61K2236/331A61K2236/39A61P35/00A61P37/04A61K33/243A61K2300/00
Inventor 钱和胡斌成玉梁郭亚辉许文倩
Owner JIANGNAN UNIV
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