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Needle-shaped all-solid-state sensor for dopamine detection and preparation method of needle-shaped all-solid-state sensor

A dopamine-sensitive film and all-solid-state technology, which is applied in the field of neurotransmitter detection, can solve the problems of difficult to realize in vivo detection and large equipment, and achieve the effect of realizing in vivo detection, reducing damage and increasing stability

Active Publication Date: 2021-05-04
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, the invention also solves the problem that the traditional equipment is large and difficult to realize in-body detection, and provides possibility for in-body detection through electrode miniaturization

Method used

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  • Needle-shaped all-solid-state sensor for dopamine detection and preparation method of needle-shaped all-solid-state sensor
  • Needle-shaped all-solid-state sensor for dopamine detection and preparation method of needle-shaped all-solid-state sensor
  • Needle-shaped all-solid-state sensor for dopamine detection and preparation method of needle-shaped all-solid-state sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0069] like figure 1 , figure 2 , image 3 As shown, a needle-shaped all-solid-state sensor for dopamine detection includes a reference electrode b and a dopamine selective electrode a. The dopamine selective electrode includes a first gold wire 6a, a first gold wire 6a One end is the selection output end, and the other end is sequentially coated with solid electrolyte layer 4a, dopamine sensitive membrane 3a, macromolecular filter layer 2a and soluble hardening layer 1a from the inside to the outside. The reference electrode includes a second gold wire. 6b, one end is the reference output end, and the other end is sequentially coated with the solid electrolyte layer 4b, the reference membrane 3b, the macromolecular filter layer 2b and the dissolvable hardening layer 1b from the inside to the outside.

[0070] Preferably, the needle-shaped all-solid-state sensor further includes an electrode holder 8, a lead wire 9a of the selective electrode, and a lead wire 9b of the refe...

preparation example 1

[0072] S01. Coat two gold wires with a diameter of 0.5mm and a purity of 99.999% on a Prussian blue insulating layer, and leave exposed parts at both ends for the coating and detection ends; use the two gold wire detection ends respectively by 1.5μm, 0.5μm and 0.05μm diameter alumina powders were prepared with 80mg / mL alumina suspension for polishing on chamois. After polishing, they were washed with deionized water, and put into 50.0% vol alcohol solution and 8.0 The sulfuric acid solution of %wt was ultrasonically cleaned for 10min, the power of ultrasonic cleaning was 200w, and then rinsed with deionized water; finally, the exposed part of the gold wire was blown dry with nitrogen without water droplets, and then placed in a drying box for drying for 20h;

[0073] S02, coating the solid electrolyte layer: the mass concentration of the conductive polymer aqueous solution is 1.3% poly-3,4-ethylenedioxythiophene monomer / polystyrene sulfonic acid aqueous solution, the mass conce...

preparation example 2

[0080] S01. Coat two gold wires with a diameter of 0.4mm and a purity of 99.99% with a Prussian blue insulating layer, and leave bare parts at both ends for coating and detection ends; The 100 mg / mL alumina suspension prepared with 1.2 μm, 0.8 μm and 0.07 μm diameter alumina powder was polished on the suede, cleaned with deionized water after grinding, and put into 45.0% vol alcohol solution and 10.0 The %wt sulfuric acid solution was ultrasonically cleaned for 10 minutes, and the power of the ultrasonic cleaning was 180w, then rinsed with deionized water, and finally dried with nitrogen to dry the exposed part of the gold wire without water droplets, and then dried in a drying oven for 15 hours;

[0081] S02. Coating a solid electrolyte layer: the poly-3,4-ethylenedioxythiophene monomer / polystyrene sulfonic acid aqueous solution with a mass concentration of 1.4% of a conductive polymer aqueous solution, and poly-3,4- with a mass concentration of 1.4wt%. Based on the total mas...

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Abstract

The invention relates to the field of neurotransmitter detection, and provides a needle-shaped all-solid-state sensor for dopamine detection and a preparation method of the needle-shaped all-solid-state sensor in order to solve the technical problems of complex operation, long time consumption, low precision, strict use conditions and the like in current dopamine detection. The needle-shaped all-solid-state sensor is simple in equipment and convenient in operation, does not need sample pretreatment, and can be used for realizing sensitive and accurate dopamine concentration detection. Meanwhile, the problems that traditional equipment is large and in-vivo detection is difficult to achieve are solved, and in-vivo detection is made possible through electrode miniaturization.

Description

technical field [0001] The invention relates to the field of neurotransmitter detection, in particular to a needle-shaped all-solid-state sensor for dopamine detection and a preparation method thereof. Background technique [0002] Dopamine is a monoamine neurotransmitter that plays a signaling role in the nervous system. Dopamine plays an important role in our perception of happiness, and is also associated with motor control, reward mechanisms and arousal, learning and memory, and more. When the function of the dopaminergic nervous system in the human brain is disturbed, the human will also appear abnormal mental state. When dopaminergic neurons are overactive, schizophrenia may occur; when dopamine secretion is insufficient, Parkinson's disease and other diseases may occur; when dopaminergic neurons in the substantia nigra are damaged or missing, people will suffer Symptoms include tremors, stiffness, and slurred speech. Therefore, monitoring the content of dopamine in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/333G01N27/28
CPCG01N27/333G01N27/3335G01N27/283G01N27/28
Inventor 王酉马思远李光
Owner ZHEJIANG UNIV
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