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A kind of needle-shaped all-solid-state sensor for histamine detection and preparation method thereof

An all-solid-state, sensor technology, applied in the field of neurotransmitter detection, can solve the problems of large equipment and difficult to achieve in vivo detection, and achieve the effects of reducing damage, realizing in vivo detection, and increasing stability

Active Publication Date: 2022-05-10
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, the invention also solves the problem that the traditional equipment is large and difficult to realize in-body detection, and provides possibility for in-body detection through electrode miniaturization

Method used

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  • A kind of needle-shaped all-solid-state sensor for histamine detection and preparation method thereof
  • A kind of needle-shaped all-solid-state sensor for histamine detection and preparation method thereof
  • A kind of needle-shaped all-solid-state sensor for histamine detection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0070] Such as figure 1 , figure 2 , image 3 As shown, a needle-shaped all-solid-state sensor for histamine detection includes a reference electrode b, a selective electrode a for histamine, and the selective electrode for histamine includes the first gold wire 6a, the first One end of the gold wire 6a is a selection output end, and the other end is sequentially coated with a solid electrolyte layer 4a, a histamine sensitive membrane 3a, a macromolecular filter layer 2a and a soluble hardening layer 1a from inside to outside, and the reference electrode includes the first Two gold wires 6b, one end is the reference output end, and the other end covers the solid electrolyte layer 4b, the reference membrane 3b, the macromolecule filter layer 2b and the soluble hardening layer 1b sequentially from inside to outside.

[0071] Preferably, the needle-shaped all-solid-state sensor further includes an electrode holder 8, a lead wire 9a of the selective electrode, and a lead wire 9...

preparation example 1

[0073] S01. Coat two gold wires with a diameter of 0.5mm and a purity of 99.999% with a Prussian blue insulating layer, and leave bare parts at both ends for coating and detection ends; 1.5μm, 0.5μm and 0.05μm diameter alumina powders are prepared with 80mg / mL alumina suspension and polished on the suede. Sulfuric acid solution of %wt was ultrasonically cleaned for 10 minutes, and the power of ultrasonic cleaning was 200w, and then rinsed with deionized water; finally, the exposed part of the gold wire was blown dry with nitrogen gas without water droplets, and dried in a drying oven for 20 hours;

[0074] S02, coating the solid electrolyte layer: the poly-3,4-ethylenedioxythiophene monomer / polystyrene sulfonic acid aqueous solution with a mass concentration of the conductive polymer aqueous solution of 1.3%, based on the total mass (volume) of the conductive polymer aqueous solution, Adding a 0.1M cetyltrimethylammonium bromide aqueous solution with a mass percentage of 1‰, a...

preparation example 2

[0081] S01. Coat two gold wires with a diameter of 0.4mm and a purity of 99.99% with a Prussian blue insulating layer, and leave bare parts at both ends for coating and detection ends; The 100 mg / mL alumina suspension prepared with 1.2 μm, 0.8 μm and 0.07 μm diameter alumina powder was polished on the suede, cleaned with deionized water after grinding, and put into 45.0% vol alcohol solution and 10.0 The %wt sulfuric acid solution was ultrasonically cleaned for 10 minutes, and the power of the ultrasonic cleaning was 180w, then rinsed with deionized water, and finally dried with nitrogen to dry the exposed part of the gold wire without water droplets, and then dried in a drying oven for 15 hours;

[0082] S02. Coating the solid electrolyte layer: add the poly-3,4-ethylenedioxythiophene monomer / polystyrene sulfonic acid aqueous solution with a mass concentration of the conductive polymer aqueous solution of 1.4%, based on the total mass of the conductive polymer aqueous solution...

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Abstract

The invention relates to the field of neurotransmitter detection. In order to solve the technical problems of complex operation, long time consumption, low precision, and strict use conditions in current histamine detection, the invention proposes a needle-shaped all-solid-state sensor for histamine detection. The preparation method thereof has simple equipment, convenient operation and no need for sample pretreatment, and can be used to realize sensitive and accurate detection of histamine concentration. At the same time, the invention also solves the problem that the traditional equipment is too large to realize in-body detection, and provides possibility for in-body detection through miniaturization of electrodes.

Description

technical field [0001] The invention relates to the field of neurotransmitter detection, in particular to a needle-shaped all-solid-state sensor for histamine detection and a preparation method thereof. Background technique [0002] Histamine is a biogenic amine synthesized from L-histidine catalyzed by decarboxylase, and is widely distributed in the human body. In the central system, histamine, as an important neurotransmitter, has the functions of arousal, hypnosis and stress response. When histaminergic neurons are dysfunctional, the human body may produce headaches, insomnia, lethargy and other symptoms, and in severe cases, it may also lead to Parkinson's disease, schizophrenia, Alzheimer's disease and cerebral ischemia and other neurological diseases; Histamine also participates in the regulation of various types of cells related to cancer development, and improves the efficacy of radiation therapy by enhancing the radiation response of cancer cells in the body; not o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/333G01N27/28
CPCG01N27/333G01N27/3335G01N27/283G01N27/28
Inventor 王酉马思远李光
Owner ZHEJIANG UNIV
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