Check patentability & draft patents in minutes with Patsnap Eureka AI!

A kind of needle-shaped all-solid-state sensor for dopamine detection and preparation method thereof

A dopamine-sensitive membrane, all-solid-state technology, applied in the field of neurotransmitter detection, can solve the problems of difficulty in in-vivo detection and large equipment, and achieve the effects of in-vivo detection, damage reduction, and interference reduction.

Active Publication Date: 2022-04-26
ZHEJIANG UNIV
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the invention also solves the problem that the traditional equipment is large and difficult to realize in-body detection, and provides possibility for in-body detection through electrode miniaturization

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of needle-shaped all-solid-state sensor for dopamine detection and preparation method thereof
  • A kind of needle-shaped all-solid-state sensor for dopamine detection and preparation method thereof
  • A kind of needle-shaped all-solid-state sensor for dopamine detection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0069] Such as figure 1 , figure 2 , image 3 As shown, a needle-shaped all-solid-state sensor for dopamine detection includes a reference electrode b, a selective electrode a for dopamine, and the selective electrode for dopamine includes a first gold wire 6a, a first gold wire 6a One end is the selection output end, and the other end is sequentially coated with a solid electrolyte layer 4a, a dopamine sensitive membrane 3a, a macromolecular filter layer 2a and a soluble hardening layer 1a from inside to outside, and the reference electrode includes a second gold wire 6b, one end is the reference output end, and the other end is covered with solid electrolyte layer 4b, reference membrane 3b, macromolecular filter layer 2b and soluble hardening layer 1b sequentially from inside to outside.

[0070] Preferably, the needle-shaped all-solid-state sensor further includes an electrode holder 8, a lead wire 9a of the selective electrode, and a lead wire 9b of the reference electr...

preparation example 1

[0072] S01. Coat two gold wires with a diameter of 0.5mm and a purity of 99.999% with a Prussian blue insulating layer, and leave bare parts at both ends for coating and detection ends; 1.5μm, 0.5μm and 0.05μm diameter alumina powders are prepared with 80mg / mL alumina suspension and polished on the suede. Sulfuric acid solution of %wt was ultrasonically cleaned for 10 minutes, and the power of ultrasonic cleaning was 200w, and then rinsed with deionized water; finally, the exposed part of the gold wire was blown dry with nitrogen gas without water droplets, and dried in a drying oven for 20 hours;

[0073] S02. Coating a solid electrolyte layer: the poly-3,4-ethylenedioxythiophene monomer / polystyrene sulfonic acid aqueous solution with a mass concentration of 1.3 wt% poly-3,4- Based on the total mass of ethylenedioxythiophene monomer / polystyrene sulfonic acid aqueous solution, add a 0.1M cetyltrimethylammonium bromide aqueous solution with a mass percentage of 1‰, and a 3% mas...

preparation example 2

[0080] S01. Coat two gold wires with a diameter of 0.4mm and a purity of 99.99% with a Prussian blue insulating layer, and leave bare parts at both ends for coating and detection ends; The 100 mg / mL alumina suspension prepared with 1.2 μm, 0.8 μm and 0.07 μm diameter alumina powder was polished on the suede, cleaned with deionized water after grinding, and put into 45.0% vol alcohol solution and 10.0 The %wt sulfuric acid solution was ultrasonically cleaned for 10 minutes, and the power of the ultrasonic cleaning was 180w, then rinsed with deionized water, and finally dried with nitrogen to dry the exposed part of the gold wire without water droplets, and then dried in a drying oven for 15 hours;

[0081] S02. Coating a solid electrolyte layer: the poly-3,4-ethylenedioxythiophene monomer / polystyrene sulfonic acid aqueous solution with a mass concentration of 1.4% of a conductive polymer aqueous solution, and poly-3,4- with a mass concentration of 1.4wt%. Based on the total mas...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to the field of neurotransmitter detection. In order to solve the technical problems of complicated operation, long time consumption, low precision, and strict use conditions in current dopamine detection, the invention proposes a needle-shaped all-solid-state sensor for dopamine detection and its The preparation method has the advantages of simple equipment, convenient operation and no need for sample pretreatment, and can be used for sensitive and accurate detection of dopamine concentration. At the same time, the invention also solves the problem that the traditional equipment is too large to realize in-body detection, and provides possibility for in-body detection through miniaturization of electrodes.

Description

technical field [0001] The invention relates to the field of neurotransmitter detection, in particular to a needle-shaped all-solid-state sensor for dopamine detection and a preparation method thereof. Background technique [0002] Dopamine is a monoamine neurotransmitter that plays a role in signaling in the nervous system. Dopamine plays an important role in the process of our perception of happiness, and is also related to motor control, reward mechanism and excitement, learning and memory, etc. When the function of the dopaminergic nervous system in the human brain is impaired, people will also experience abnormal mental states. When dopaminergic neurons are overactive, schizophrenia may occur; when dopamine is insufficiently secreted, diseases such as Parkinson's disease will occur; when dopaminergic neurons in the substantia nigra of the midbrain are damaged or missing, people will develop Symptoms include tremors, stiffness, and slurred speech. Therefore, monitorin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/333G01N27/28
CPCG01N27/333G01N27/3335G01N27/283G01N27/28
Inventor 王酉马思远李光
Owner ZHEJIANG UNIV
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com