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A needle-like all-solid-state sensor for phenethylamine detection and its preparation method

A phenylethylamine and all-solid-state technology, applied in the field of neurotransmitter detection, can solve the problems of difficult to realize in vivo detection and large equipment, and achieve the effects of in vivo detection, reduced damage, and easy storage and use

Active Publication Date: 2022-05-10
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, the invention also solves the problem that the traditional equipment is large and difficult to realize in-body detection, and provides possibility for in-body detection through electrode miniaturization

Method used

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  • A needle-like all-solid-state sensor for phenethylamine detection and its preparation method
  • A needle-like all-solid-state sensor for phenethylamine detection and its preparation method
  • A needle-like all-solid-state sensor for phenethylamine detection and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0069] Such as figure 1 , figure 2 , image 3 As shown, a needle-shaped all-solid-state sensor for phenylethylamine detection includes a reference electrode b, a selective electrode a of phenylethylamine, and the phenylethylamine selective electrode includes the first gold wire 6a, One end of the first gold wire 6a is the selection output end, and the other end is sequentially coated with the solid electrolyte layer 4a, the phenethylamine sensitive membrane 3a, the macromolecule filter layer 2a and the soluble hardening layer 1a from the inside to the outside. The specific electrode includes a second gold wire 6b, one end is a reference output end, and the other end is covered with a solid electrolyte layer 4b, a reference membrane 3b, a macromolecule filter layer 2b and a soluble hardening layer 1b sequentially from inside to outside.

[0070] Preferably, the needle-shaped all-solid-state sensor further includes an electrode holder 8, a lead wire 9a of the selective electr...

preparation example 1S01

[0071] Preparation Example 1S01. Coat two gold wires with a diameter of 0.5mm and a purity of 99.999% with a Prussian blue insulating layer, and leave exposed parts at both ends for coating and detection ends; separate the two gold wire detection ends Use 1.5μm, 0.5μm and 0.05μm diameter alumina powder to prepare 80mg / mL alumina suspension to polish on the suede. After polishing, wash with deionized water and put in 50.0% vol alcohol solution Ultrasonic cleaning with 8.0%wt sulfuric acid solution for 10 minutes respectively, the power of ultrasonic cleaning is 200w, and then rinse with deionized water; finally, dry the exposed part of the gold wire with nitrogen gas without water droplets, and put it in a drying oven for drying for 20 hours;

[0072] S02. Coating a solid electrolyte layer: the poly-3,4-ethylenedioxythiophene monomer / polystyrene sulfonic acid aqueous solution with a mass concentration of 1.3 wt% poly-3,4- Based on the total mass of ethylenedioxythiophene monome...

preparation example 2

[0079] S01. Coat two gold wires with a diameter of 0.4mm and a purity of 99.99% with a Prussian blue insulating layer, and leave bare parts at both ends for coating and detection ends; The 100 mg / mL alumina suspension prepared with 1.2 μm, 0.8 μm and 0.07 μm diameter alumina powder was polished on the suede, cleaned with deionized water after grinding, and put into 45.0% vol alcohol solution and 10.0 The %wt sulfuric acid solution was ultrasonically cleaned for 10 minutes, and the power of the ultrasonic cleaning was 180w, then rinsed with deionized water, and finally dried with nitrogen to dry the exposed part of the gold wire without water droplets, and then dried in a drying oven for 15 hours;

[0080] S02. Coating a solid electrolyte layer: the poly-3,4-ethylenedioxythiophene monomer / polystyrene sulfonic acid aqueous solution with a mass concentration of 1.4% of a conductive polymer aqueous solution, and poly-3,4- with a mass concentration of 1.4wt%. Based on the total mas...

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Abstract

The invention relates to the field of neurotransmitter detection. In order to solve the technical problems of complex operation, long time consumption, low precision and strict use conditions in the current detection of phenylethylamine, the invention proposes a needle-shaped neurotransmitter for the detection of phenylethylamine. The solid-state sensor and the preparation method thereof have simple equipment, convenient operation and no need for sample pretreatment, and can be used to realize sensitive and accurate detection of phenethylamine concentration. At the same time, the invention also solves the problem that the traditional equipment is too large to realize in-body detection, and provides possibility for in-body detection through miniaturization of electrodes.

Description

technical field [0001] The invention relates to the field of neurotransmitter detection, in particular to a needle-shaped all-solid-state sensor for phenethylamine detection and a preparation method thereof. Background technique [0002] Phenylethylamine is an alkaloid and monoamine neurotransmitter that naturally exists in the human body and can be used to increase the concentration of dopamine in interstitial fluid and also to inhibit the activation of dopamine nerves. Phenylethylamine stimulates the body to produce certain chemicals that play a role in depression and other mental illnesses, and are closely related to a person's concentration, athletic performance and emotional states such as depression. Although phenethylamine has a short half-life, it affects the mental status of humans by enhancing catecholaminergic nerve transmission and inducing striatal hyperresponsiveness. When the level of phenylethylamine in the human body is low, it can produce symptoms such as ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/333G01N27/28
CPCG01N27/333G01N27/3335G01N27/283G01N27/28
Inventor 王酉马思远李光
Owner ZHEJIANG UNIV
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