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A kind of porous spherical carbon adsorption material with blood compatibility and preparation method thereof

A blood-compatible, porous spherical technology, applied in the preparation/purification of carbon, blood circulation treatment, chemical instruments and methods, etc., can solve the problems of uneven dispersion, poor monodispersity, large pressure difference, etc., and achieve the preparation process simple effect

Active Publication Date: 2022-04-08
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Hollow carbon microspheres have a well-developed pore structure, and also have good chemical and thermal stability. There are many preparation methods, among which the template method is currently widely used, but there are still some shortcomings in the existing synthesis process: For example, the template preparation process is cumbersome and the dispersion is uneven; it is necessary to accurately add surfactants, pore expanders, etc. in multiple steps; and the prepared hollow carbon microspheres are mostly wall-adhesive, and the monodispersity is poor.
At present, it is reported that two-dimensional materials such as graphene are combined with hollow carbon microspheres to prepare macroscopic bodies (Sep. Purif. Technol. 2019, 15, 524). However, in this method, on the one hand, graphene is easy to Coating the surface of the hollow carbon microspheres makes the well-developed pores of the carbon microspheres blocked, and the hollow carbon microspheres only play the role of supporting the skeleton, and its excellent adsorption performance cannot be exerted; on the other hand, the obtained massive random Airgel not only has low strength, but also it is difficult for blood to flow through the middle in actual hemoperfusion, which will generate a large pressure difference, and the sharp edges and corners are easy to damage normal cells, resulting in poor blood compatibility, etc., and cannot be used in blood. Perfusion application

Method used

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  • A kind of porous spherical carbon adsorption material with blood compatibility and preparation method thereof
  • A kind of porous spherical carbon adsorption material with blood compatibility and preparation method thereof
  • A kind of porous spherical carbon adsorption material with blood compatibility and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0051] 1) Prepare a mixed solution of methyl orthosilicate, ethanol, ammonia water and water, stir at 750rpm at 20°C for 180min, then add resorcinol and formaldehyde, the reaction conditions remain unchanged, continue to stir, and after fully reacting for 21h, add The solution is centrifuged, filtered, washed and dried to obtain carbon / silicon composite microspheres;

[0052] 2) Put carbon / silicon composite microspheres into a tube furnace for carbonization, use an argon atmosphere, heat up to 700°C at a heating rate of 5°C / min, and then hold for 3 hours;

[0053] 3) Prepare a sodium hydroxide solution with a molar concentration of 1 mol / L, put 1 g of the carbonized sample into 300 mL of sodium hydroxide solution, condense and reflux at 80 ° C for 3 hours, and filter the solution after fully reacting, washing and drying to obtain Hollow carbon microspheres;

[0054] 4) configure the hollow carbon microsphere dispersion of 0.5wt% concentration, add dodecyl dimethyl betaine, an...

Embodiment 2

[0059] 1) Prepare a mixed solution of tetraethyl orthosilicate, ethanol, ammonia water, resorcinol, formaldehyde and water, stir at 750rpm at 35°C, and centrifuge the solution after fully reacting for 24 hours, suction filter, wash and dry Obtain carbon / silicon composite microspheres;

[0060] 2) Put carbon / silicon composite microspheres into a tube furnace for carbonization, use an argon atmosphere, heat up to 700°C at a heating rate of 3°C / min, and then hold for 5 hours;

[0061] 3) Prepare a sodium hydroxide solution with a molar concentration of 1 mol / L, put 1 g of the carbonized sample into 300 mL of sodium hydroxide solution, condense and reflux at 90 ° C for 2 hours, and filter the solution after fully reacting, washing and drying to obtain Hollow carbon microspheres;

[0062] 4) configure a chitosan solution with a concentration of 3wt%, and simultaneously configure a dispersion of hollow carbon microspheres with a concentration of 0.2wt%, add dodecyl sulfopropyl beta...

Embodiment 3

[0067] 1) Prepare a mixed solution of tetraethyl orthosilicate, ethanol, ammonia water and water, stir at 500rpm at 10°C for 30 minutes, then add catechol and formaldehyde, keep stirring under the same reaction conditions, and then add catechol and formaldehyde after fully reacting for 18 hours The solution is centrifuged, filtered, washed and dried to obtain carbon / silicon composite microspheres;

[0068] 2) Put carbon / silicon composite microspheres into a tube furnace for carbonization, use an argon atmosphere, heat up to 700°C at a heating rate of 2°C / min, and then keep warm for 2h;

[0069] 3) Prepare a potassium hydroxide solution with a molar concentration of 1 mol / L, put 1 g of the carbonized sample into 300 mL of potassium hydroxide solution, condense and reflux at 85°C for 2 hours, and filter the solution after fully reacting, washing and drying to obtain Hollow carbon microspheres;

[0070] 4) Prepare a sodium alginate solution with a concentration of 3wt%, and at t...

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Abstract

The invention discloses a porous spherical carbon adsorption material with blood compatibility, which belongs to the technical field of material preparation. The porous spherical carbon adsorption material is a composite carbon sphere; the composite carbon sphere is composed of single-layer or multi-layer hollow carbon The microspheres are self-assembled under the action of the binder; the multi-level pore structure is as follows: the first level is the micron-scale radial pore channel from the surface of the composite carbon sphere to the interior, and the second level is the internal connection of the large pore channels of the composite carbon sphere The submicron pore structure between them, the pore walls of the primary and secondary pore structures are composed of hollow carbon microspheres and binders, and the third level is the nanoscale pore structure of the hollow carbon microspheres that make up the composite carbon spheres. The porous spherical carbon adsorption material described in this application has good adsorption properties for various adsorbents, especially for medium and large molecular toxins, and has good blood compatibility. , Water treatment and other adsorption fields have a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of material preparation, in particular to a porous spherical carbon adsorption material with blood compatibility and a preparation method thereof. Background technique [0002] Hemoperfusion refers to the introduction of the patient's blood outside the body through specific equipment. In the extracorporeal circulation system, the adsorbent in the hemoperfusion device removes various toxins in the blood that cannot be metabolized by the patient, especially the medium and large toxins that cannot be removed by hemodialysis. Molecular toxins, which play an irreplaceable and important role in the treatment of uremia, acute poisoning and immune system diseases. At present, the hemoperfusion adsorbent mainly represented by activated carbon in the domestic market, although it has a relatively high specific surface area, is mainly composed of micropores below 2nm, and hardly adsorbs or absorbs medium and large molec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/20B01J20/28B01J20/30C01B32/05C02F1/28A61M1/38
CPCB01J20/20B01J20/28054B01J20/28059B01J20/28061B01J20/28069B01J20/28016B01J20/28004A61M1/38C02F1/283C01B32/05
Inventor 巩前明李愉珧杜锴
Owner TSINGHUA UNIV
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