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Progesterone production process

A production process and progesterone technology, applied in the directions of steroids, organic chemistry, etc., can solve the problems of difficult separation and extraction of toluene, large pollution, etc., and achieve the effect of reducing pollution

Inactive Publication Date: 2021-05-28
河北今水生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, due to the fact that people will produce more waste liquids during the processing of progesterone, the waste liquids containing toluene are difficult to handle, and the pollution caused is relatively large. The reason is that it is difficult to separate and extract the toluene in the waste liquids. For this reason, we Propose a progesterone production process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Propose a kind of progesterone production technology in the present embodiment, comprise the steps:

[0027] Step 1: Pregnenolone, toluene, cyclohexanone, aluminum isopropoxide, dilute sulfuric acid and extractant are prepared;

[0028] Step 2: Dry the toluene, then prepare a dry reaction pot and put the dry toluene into it, add cyclohexanone and pregnenolone, stir to dissolve, steam the toluene to dehydrate to the end;

[0029] Step 3: After dehydration of toluene in step 2, quickly add aluminum isopropoxide for oxidation reaction, and cool naturally to about 80°C;

[0030] Step 4: Add 5% dilute sulfuric acid under stirring in step 3, let stand to separate layers, and separate the water layer to obtain the toluene layer;

[0031] Step 5: The toluene layer is washed with water to neutrality and then steam distilled to remove toluene and cyclohexanone;

[0032] Step 6: Cool the product obtained in step 5, filter it, stir the filter residue into a slurry form with an ex...

Embodiment 2

[0042] Propose a kind of progesterone production technology in the present embodiment, comprise the steps:

[0043] Step 1: Pregnenolone, toluene, cyclohexanone, aluminum isopropoxide, dilute sulfuric acid and extractant are prepared;

[0044] Step 2: Dry the toluene, then prepare a dry reaction pot and put the dry toluene into it, add cyclohexanone and pregnenolone, stir to dissolve, steam the toluene to dehydrate to the end;

[0045] Step 3: After dehydration of toluene in step 2, quickly add aluminum isopropoxide for oxidation reaction, and cool naturally to about 80°C;

[0046] Step 4: Add 6% dilute sulfuric acid under stirring in step 3, let stand to separate layers, separate the water layer, and obtain the toluene layer;

[0047] Step 5: The toluene layer is washed with water to neutrality and then steam distilled to remove toluene and cyclohexanone;

[0048] Step 6: Cool the product obtained in step 5, filter it, stir the filter residue into a slurry form with an extr...

Embodiment 3

[0058] Propose a kind of progesterone production technology in the present embodiment, comprise the steps:

[0059] Step 1: Pregnenolone, toluene, cyclohexanone, aluminum isopropoxide, dilute sulfuric acid and extractant are prepared;

[0060] Step 2: Dry the toluene, then prepare a dry reaction pot and put the dry toluene into it, add cyclohexanone and pregnenolone, stir to dissolve, steam the toluene to dehydrate to the end;

[0061] Step 3: After dehydration of toluene in step 2, quickly add aluminum isopropoxide for oxidation reaction, and cool naturally to about 80°C;

[0062] Step 4: Add 7% dilute sulfuric acid under stirring in step 3, let stand to separate layers, separate the water layer, and obtain the toluene layer;

[0063] Step 5: The toluene layer is washed with water to neutrality and then steam distilled to remove toluene and cyclohexanone;

[0064] Step 6: Cool the product obtained in step 5, filter it, stir the filter residue into a slurry form with an extr...

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Abstract

The invention discloses a progesterone production process which comprises the following steps: step 1, preparing pregnenolone, methylbenzene, cyclohexanone, aluminum isopropoxide, dilute sulphuric acid and an extracting agent; step 2, drying toluene, then preparing a dry reaction pot, putting the dry toluene into the reaction pot, adding cyclohexanone and pregnenolone, stirring and dissolving, and steaming toluene to dehydrate completely; step 3, after the toluene in the step 2 is dehydrated completely, rapidly adding aluminum isopropoxide for oxidation reaction, and performing natural cooling to about 80 DEG C; step 4, adding 5% dilute sulphuric acid while stirring in the step 3, standing for layering, and removing a water layer to obtain a toluene layer; and step 5, washing the toluene layer with water until the toluene layer is neutral, and carrying out steam distillation to distill toluene and cyclohexanone. According to the scheme provided by the invention, the waste liquid generated during production can be processed, so that toluene in the waste liquid is extracted and separated, pollution can be effectively reduced, and the separated toluene can be continuously utilized in the subsequent process.

Description

technical field [0001] The invention relates to the technical field of preparation of steroid hormone drug intermediates, in particular to a progesterone production process. Background technique [0002] Progesterone, also known as progesterone hormone and luteinizing hormone, is the main biologically active progesterone secreted by the ovary, with a molecular formula of C21H30O2. Before ovulation, the amount of progesterone hormone produced per day is 2 to 3 mg, mainly from the ovary. [0003] However, due to the fact that people will produce more waste liquids during the processing of progesterone, the waste liquids containing toluene are difficult to handle, and the pollution caused is relatively large. The reason is that it is difficult to separate and extract the toluene in the waste liquids. For this reason, we A progesterone production process is proposed. Contents of the invention [0004] Based on the technical problems existing in the background technology, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J7/00
CPCC07J7/002
Inventor 杨志伟
Owner 河北今水生物科技有限公司
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