Circular RNA hsa_circ_0001550 and application thereof

Abstract

The invention discloses a circular RNA hsa_circ_0001550 and an application thereof. The nucleotide sequence of the annular RNA hsa_circ_0001550 is shown as SEQ ID No: 1, the hsa_circ_0001550 can participate in generation and development of RIF by inhibiting the periostracum periostracum process, meanwhile, the hsa_circ_0001550 plays a molecular function through miRNA and mRNA and participates in related signal channels in the endometrial interstitial cell deciduation process to adjust the receiving state of endometrium on an embryo in the implantation window period, thus, the circular RNA hsa_circ_0001550 can be used as a marker for detecting the abnormal state of deciduation of the female endometrial interstitial cells, or the circular RNA hsa_circ_0001550 has a good application prospect as a medicine for regulating and controlling the deciduation of the human endometrial interstitial cells.

Description

technical field [0001] The invention belongs to the technical field of genetic engineering, and in particular relates to a circular RNA hsa_circ_0001550 and its application. Background technique [0002] Embryo implantation refers to the process of active embryos positioning, adhering, invading, and finally establishing a close connection with the endometrium in a receptive state, which is the key and initial link of successful pregnancy. Embryo implantation depends on two key factors, embryo quality and endometrial receptivity. At present, most scholars believe that if the number of transfers > 3 times or the transfer of high-quality embryos > 10 still fails to conceive, it is called Repeated Implantation Failure (RIF). With the continuous development of assisted reproductive technology (Assisted Reproductive Technology, ART), the implantation rate of In Vitro Fertilization and Embryo Transfer (IVF-ET) has reached about 50% in the past two decades, but for repeated ...

AI Technical Summary

Problems solved by technology

With the continuous development of assisted reproductive technology (Assisted Reproductive Technology, ART), the implantation rate of In Vitro Fertilization and Embryo Transfer (IVF-ET) has reached about 50% in the past two decades, but for repeated There are still challenges in patients with implant failure. The decidualization of endometrial stromal cells is a crucial biological process that occurs during the implantation window. Abnormal decidualization of endometrial stromal cells is likely to lead to implantation in such patients. The main reason for the failure, however, is the current lack of molecular-level understanding of abnormal decidualization of human endometrial stromal cells

Images